Abstract

An ideal wound dressing is highly desired for the repair of chronic wounds which should provide a moist environment, self-healing, antibacterial properties etc. Here, a novel injectable antibacterial chitosan hydrogel with good self-healing and improved mechanical properties has been prepared by dialdehyde bacterial cellulose (DABC) nanofibers as the non-toxic biocrosslinker. It is the first time to prepare the all-natural chitosan hydrogels by using ascorbic acid (VC) as solvent to dissolve chitosan and the natural fiber DABC as reinforcing and crosslinking agent. Then, the disadvantage of the use of acetic acid in the medical field was overcome and the other toxic crosslinking agents were abandoned. Accordingly, this work provides a new strategy towards fabricating the self-healing hydrogel with injectable and antibacterial properties. The new multifunctional hydrogels demonstrate strong potentiality in wound dressings or tissue engineering.

中文翻译：

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具有自愈和抗菌特性的纯天然可注射水凝胶，可用于伤口包扎

抽象的

理想的伤口敷料是修复慢性伤口的理想方法，该伤口敷料应提供潮湿的环境，自我修复，抗菌特性等。在此，由二醛制备了具有良好自我修复特性和改善的机械性能的新型可注射抗菌壳聚糖水凝胶。细菌纤维素（DABC）纳米纤维作为无毒生物交联剂。以抗坏血酸（VC）为溶剂溶解壳聚糖，以天然纤维DABC为补强剂和交联剂，是首次制备纯天然壳聚糖水凝胶。然后，克服了在医学领域使用乙酸的缺点，并放弃了其他有毒的交联剂。因此，这项工作为制备具有可注射和抗菌特性的自愈水凝胶提供了新的策略。