Dicobalt hexacarbonyl nucleoside complexes of propargyl ether or esters of 5-substituted uridines react with diverse C-nucleophiles. Synthetic outcomes confirmed that the Nicholas reaction can be carried out in a nucleoside presence, leading to a divergent synthesis of novel metallo-nucleosides enriched with alkene, arene, arylketo, and heterocyclic functions, in the deoxy and ribo series.

中文翻译：

---

使用Nicholas反应在修饰的有机金属核苷中通过CC键形成5-炔基尿苷侧链的延伸。

炔丙基醚或5-取代的尿苷的酯的二钴六羰基核苷络合物与各种C-亲核试剂反应。合成结果证实，尼古拉斯反应可在核苷存在下进行，从而导致脱氧和核糖系列中富含烯烃，芳烃，芳基酮和杂环功能的新型金属核苷的发散合成。