Abstract Conventional cancer therapy methods are thought to be replaced by photothermal therapy in near future due to less invasive, less consuming, and highly selective therapeutic features of the latter. Implementing photothermal therapy in practice requires development of multifunctional and efficient photosensitizing agents. The purpose of this study is to develop a magnetic nanocomposite with excellent photothermal performance. A ternary nanocomposite (S-rGO-Fe3O4-PANI) was synthesized by a facile two-step method, including solvothermal co-reduction of graphene oxide and iron nitrate followed by in situ polymerization of PVA stabilized polyaniline. The nanocomposite was characterized with UV–vis, FTIR, XRD, VSM, and SEM, and photothermal properties were investigated with an 808 nm NIR laser. 1 mL of the aqueous dispersions of the nanocomposites at 25, 50, and 100 μg mL−1 concentrations were irradiated at 1.5, 2.0, and 3.0 W.cm-2 laser power densities. Photothermal conversion efficiency was calculated by time constant method and 86.3 % efficiency was obtained from the 100 μg mL−1 nanocomposite at 2.0 W.cm-2 laser power density with a maximum temperature difference of 56.7 °C. S-rGO-Fe3O4-PANI demonstrated excellent photothermal performance and is a promising candidate for photothermal therapy, targeted delivery, and imaging applications.

中文翻译：

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还原氧化石墨烯-氧化铁-聚苯胺三元纳米复合材料的合成、表征及其光热性能测定

摘要 传统的癌症治疗方法被认为在不久的将来会被光热疗法所取代，因为后者具有微创、低消耗和高选择性的治疗特点。在实践中实施光热疗法​​需要开发多功能高效的光敏剂。本研究的目的是开发具有优异光热性能的磁性纳米复合材料。三元纳米复合材料 (S-rGO-Fe3O4-PANI) 通过简便的两步法合成，包括氧化石墨烯和硝酸铁的溶剂热共还原，然后原位聚合 PVA 稳定的聚苯胺。纳米复合材料用紫外-可见光、红外光谱、XRD、VSM 和 SEM 进行表征，并用 808 nm 近红外激光研究光热性能。在 1.5、2.0 和 3.0 W.cm-2 激光功率密度下照射 1 mL 浓度为 25、50 和 100 μg mL-1 的纳米复合材料的水分散体。通过时间常数方法计算光热转换效率，在 2.0 W.cm-2 激光功率密度和 56.7 °C 的最大温差下，从 100 μg mL-1 纳米复合材料获得 86.3% 的效率。S-rGO-Fe3O4-PANI 表现出优异的光热性能，是光热疗法、靶向递送和成像应用的有希望的候选者。cm-2 激光功率密度，最大温差为 56.7 °C。S-rGO-Fe3O4-PANI 表现出优异的光热性能，是光热疗法、靶向递送和成像应用的有希望的候选者。cm-2 激光功率密度，最大温差为 56.7 °C。S-rGO-Fe3O4-PANI 表现出优异的光热性能，是光热疗法、靶向递送和成像应用的有希望的候选者。