Because of a highly branched architecture and a large number of functional groups on the molecular periphery, biodegradable and commercially available aliphatic hyperbranched 2,2-bis(methylol)propionic acid-based polyesters have a wide variety of applications in coatings, additives, tougheners, hybrid materials, drug carriers, and macromolecular building blocks. One of the most interesting applications is the synthesis of amphiphilic hyperbranched copolymers with an aliphatic hyperbranched 2,2-bis(methylol)propionic acid-based polyester core. In this Review, developments in the synthesis of amphiphilic hyperbranched copolymers are presented in terms of Boltorn™ Hx (x = 20, 30, 40), a series of commercial aliphatic hyperbranched polyesters. Applications include drug delivery, transfection, bio-imaging, and nanoparticle preparation. Challenges and perspectives for future developments are discussed as well.

中文翻译：

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脂族超支化2,2-双（羟甲基）丙酸基聚酯核的两亲性超支化共聚物的研究进展

由于高度支化的体系结构和分子外围的大量官能团，可生物降解的市售脂族超支化2，2-双（羟甲基）丙酸基聚酯在涂料，添加剂，增韧剂，杂种材料，药物载体和高分子构件。最有趣的应用之一是合成具有脂族超支化2，2-双（羟甲基）丙酸基聚酯核的两亲性超支化共聚物。在本综述中，以Boltorn™H x（x= 20、30、40），一系列商品化的脂肪族超支化聚酯。应用包括药物递送，转染，生物成像和纳米颗粒制备。还讨论了未来发展的挑战和前景。