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Insights to the action of additives for stabilization of ultrafine particles of Fenofibrate in aqueous suspensions produced by Sonoprecipitation
Powder Technology ( IF 5.2 ) Pub Date : 2020-03-01 , DOI: 10.1016/j.powtec.2019.12.059
Komal U. Pandey , Sendhil K. Poornachary , Sameer V. Dalvi

Abstract Sonoprecipitation of Fenofibrate (FNB) was carried out in the presence of polymeric additives and surfactants. The particle size and morphology was found to be significantly affected by the mixing conditions and the type of additives used. In order to understand the mechanism by which the additives affect FNB particle growth and morphology, intermolecular interactions between the additive and FNB crystal surfaces were modeled. Among the additives used, Tween 80 was found to be a great habit modifier. Hydrogen bonding interactions between Tween 80 and FNB molecules exposed on the (010) face of FNB particles leads to a needle-like morphology. The experimental and modelling studies indicate that hydroxyl propyl methyl cellulose (HPMC) and bovine serum albumin (BSA) show stronger crystal growth inhibition effect and provide better stabilization compared to polyvinyl pyrolidone (PVP) and Tween 80. FNB particles precipitated with ultrasound and additives were found to exhibit faster drug release profiles compared to the particles precipitated without ultrasound but in the presence of additives.

中文翻译:

深入了解添加剂在通过声沉淀法生产的水悬浮液中稳定非诺贝特超细颗粒的作用

摘要 在聚合物添加剂和表面活性剂的存在下进行非诺贝特 (FNB) 的声沉淀。发现颗粒大小和形态受混合条件和所用添加剂类型的显着影响。为了了解添加剂影响 FNB 颗粒生长和形态的机制,对添加剂和 FNB 晶体表面之间的分子间相互作用进行了建模。在使用的添加剂中,发现吐温 80 是一种很好的习性调节剂。吐温 80 和暴露在 FNB 颗粒 (010) 面上的 FNB 分子之间的氢键相互作用导致针状形态。
更新日期:2020-03-01
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