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Prediagnostic symptoms and signs of adult glioma: the patients' view.
Journal of Neuro-Oncology ( IF 3.9 ) Pub Date : 2020-01-01 , DOI: 10.1007/s11060-019-03373-y
Marthe C M Peeters 1 , Linda Dirven 1, 2 , Johan A F Koekkoek 1, 2 , Ellen G Gortmaker 2 , Lara Fritz 2 , Maaike J Vos 2 , Martin J B Taphoorn 1, 2
Affiliation  

BACKGROUND Little is known about the symptoms glioma patients experience in the year before diagnosis, either or not resulting in health care usage. This study aimed to determine the incidence of symptoms glioma patients experienced in the year prior to diagnosis, and subsequent visits to a general practitioner (GP). METHODS Glioma patients were asked to complete a 30-item study-specific questionnaire focusing on symptoms they experienced in the 12 months before diagnosis. For each indicated symptom, patients were asked whether they consulted the GP for this issue. RESULTS Fifty-nine patients completed the questionnaires, 54 (93%) with input of a proxy. The median time since diagnosis was 4 months (range 1-12). The median number of symptoms experienced in the year before diagnosis was similar between gliomas with favourable and poor prognosis, i.e. 6 (range 0-24), as were the five most frequently mentioned problems: fatigue (n = 34, 58%), mental tiredness (n = 30, 51%), sleeping disorder (n = 24, 41%), headache (n = 23, 39%) and stress (n = 20, 34%). Twenty-six (44%) patients visited the GP with at least one issue. Patients who did consult their GP reported significantly more often muscle weakness (11 vs 3, p = 0.003) than patients who did not, which remained significant after correction for multiple testing, which was not the case for paralysis in hand/leg (10 vs 4), focussing (11 vs 6) or a change in awareness (9 vs 4). CONCLUSIONS Glioma patients experience a range of non-specific problems in the year prior to diagnosis, but only patients who consult the GP report more often neurological problems.

中文翻译:

成人神经胶质瘤的诊断前症状和体征:患者的观点。

背景技术关于神经胶质瘤患者在诊断之前一年中经历的症状(无论是否导致医疗保健使用)知之甚少。这项研究旨在确定诊断前一年以及随后就诊的全科医生(神经胶质瘤)的症状发生率。方法胶质瘤患者被要求填写一份30项针对研究的问卷,重点针对他们在诊断前12个月中所经历的症状。对于每种指示的症状,询问患者是否就此问题咨询了GP。结果59名患者完成了调查问卷,其中54名(93%)接受了代理人的输入。自诊断以来的中位时间为4个月(范围1-12)。预后良好和不良的神经胶质瘤在诊断前一年中出现的症状中位数相似,即。e。6(范围为0-24),以及最常提到的五个问题:疲劳(n = 34,58%),精神疲劳(n = 30,51%),睡眠障碍(n = 24,41%),头痛(n = 23,39%)和压力(n = 20,34%)。26例(44%)患者至少有1期就诊了GP。进行过GP咨询的患者报告的肌肉无力情况明显多于未进行过GP咨询的患者(11 vs 3,p = 0.003),经多次测试校正后仍显着,而手/腿麻痹则不然(10vs。 4),专注(11 vs 6)或意识改变(9 vs 4)。结论胶质瘤患者在诊断前一年中遇到了一系列非特异性问题,但只有咨询GP的患者报告神经系统疾病的频率更高。58%),精神疲劳(n = 30,51%),睡眠障碍(n = 24,41%),头痛(n = 23,39%)和压力(n = 20,34%)。26例(44%)患者至少有1期就诊了GP。进行过GP咨询的患者报告的肌肉无力情况明显多于未进行过GP咨询的患者(11 vs 3,p = 0.003),经多次测试校正后仍显着,而手/腿麻痹则不然(10vs。 4),专注(11 vs 6)或意识改变(9 vs 4)。结论胶质瘤患者在诊断前一年中遇到了一系列非特异性问题,但只有咨询GP的患者报告神经系统疾病的频率更高。58%),精神疲劳(n = 30,51%),睡眠障碍(n = 24,41%),头痛(n = 23,39%)和压力(n = 20,34%)。26例(44%)患者至少有1期就诊了GP。进行过GP咨询的患者报告的肌肉无力情况明显多于未进行过GP咨询的患者(11 vs 3,p = 0.003),经多次测试校正后仍显着,而手/腿麻痹则不然(10vs。 4),专注(11 vs 6)或意识改变(9 vs 4)。结论胶质瘤患者在诊断前一年中遇到了一系列非特异性问题,但只有咨询GP的患者报告神经系统疾病的频率更高。26例(44%)患者至少有1期就诊了GP。进行过GP咨询的患者报告的肌肉无力情况明显多于未进行过GP咨询的患者(11 vs 3,p = 0.003),经多次测试校正后仍显着,而手/腿麻痹则不然(10vs。 4),专注(11 vs 6)或意识改变(9 vs 4)。结论胶质瘤患者在诊断前一年中遇到了一系列非特异性问题,但只有咨询GP的患者报告神经系统疾病的频率更高。26例(44%)患者至少有1期就诊了GP。进行过GP咨询的患者报告的肌肉无力情况明显多于未进行过GP咨询的患者(11 vs 3,p = 0.003),经多次测试校正后仍显着,而手/腿麻痹则不然(10vs。 4),专注(11 vs 6)或意识改变(9 vs 4)。结论胶质瘤患者在诊断前一年中遇到了一系列非特异性问题,但只有咨询GP的患者报告神经系统疾病的频率更高。专注(11 vs 6)或意识改变(9 vs 4)。结论胶质瘤患者在诊断前一年中遇到了一系列非特异性问题,但只有咨询GP的患者报告神经系统疾病的频率更高。专注(11 vs 6)或意识改变(9 vs 4)。结论胶质瘤患者在诊断前一年中遇到了一系列非特异性问题,但只有咨询GP的患者报告神经系统疾病的频率更高。
更新日期:2020-01-01
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