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Risk of diabetes among related and unrelated family members.
Diabetes Research and Clinical Practice ( IF 5.1 ) Pub Date : 2019-12-31 , DOI: 10.1016/j.diabres.2019.107997
Kristian Aasbjerg 1 , Caroline Holm Nørgaard 2 , Nanna Vestergaard 1 , Peter Søgaard 3 , Lars Køber 4 , Peter Weeke 4 , Gunnar Gislason 5 , Christian Torp-Pedersen 2
Affiliation  

AIMS The aim was to explore familial aggregation of diabetes in genetically related and unrelated individuals. METHODS We included citizens from Danish nationwide registries between 1995 and 2018 and calculated rate ratios (RR) of diabetes based on family relation using Poisson regression. RESULTS Of 7.3 million individuals eligible for inclusion, we identified 343,237 (4.7%) with diabetes. The RR of diabetes was 2.02 (95% CI: 1.99-2.05; p < 0.0001) if any relative had diabetes, 1.79 (95% CI: 1.76-1.83) if a father had diabetes, and 2.06 (95% CI: 2.02-2.10) if a mother had diabetes. If both parents had diabetes, the RR was 3.40 (95% CI: 3.24-3.56). Among full siblings, the RR for developing diabetes was 2.77 (95% CI: 2.71-2.84) and 5.76 (95% CI: 5.00-6.63) for twins. For second-degree relatives, half siblings with a common mother had a RR of 2.35 (95% CI: 2.15-2.56), and with a common father 1.99 (95% CI: 1.81-2.17). Furthermore, the RR was 1.60 (95% CI: 1.56-1.64) if a wife had diabetes, and 1.41 (95% CI: 1.38-1.44) if a husband had diabetes. A subgroup analysis of individuals receiving insulin only treatment (N = 23,054) demonstrated a similar risk pattern, although with slightly higher risk estimates. CONCLUSIONS/INTERPRETATION Family aggregation of diabetes is associated with genetic disposition with maternal status being the predominant factor. Furthermore, we observed increased risk of diabetes in second-degree relatives, and between unrelated spouses, indicating that environmental factors influence diabetes risk substantially.

中文翻译:

相关和不相关家庭成员中患糖尿病的风险。

目的目的是探讨遗传相关和无关的个体的家族性糖尿病聚集。方法我们纳入了1995年至2018年间来自丹麦全国注册机构的公民,并根据家庭关系使用Poisson回归计算了糖尿病的比率(RR)。结果在730万符合纳入条件的个体中,我们确定了343,237(4.7%)名糖尿病患者。如果任何亲戚患有糖尿病,则糖尿病的RR为2.02(95%CI:1.99-2.05; p <0.0001),如果父亲患有糖尿病,则糖尿病的RR为1.79(95%CI:1.76-1.83),以及2.06(95%CI:2.02-) 2.10)如果母亲患有糖尿病。如果父母双方都患有糖尿病,则RR为3.40(95%CI:3.24-3.56)。在全兄弟姐妹中,双胞胎患糖尿病的RR为2.77(95%CI:2.71-2.84)和5.76(95%CI:5.00-6.63)。对于二级亲戚 有同母异母的半兄弟姐妹的RR为2.35(95%CI:2.15-2.56),同父异母兄弟有1.99(95%CI:1.81-2.17)。此外,如果妻子患有糖尿病,则RR为1.60(95%CI:1.56-1.64),如果丈​​夫患有糖尿病,则RR为1.41(95%CI:1.38-1.44)。对仅接受胰岛素治疗的个体进行的亚组分析(N = 23,054)显示出相似的风险模式,尽管其风险估计值略高。结论/解释糖尿病的家庭聚集与遗传倾向有关,而孕产妇的状况是主要因素。此外,我们观察到二级亲属以及不相关配偶之间患糖尿病的风险增加,这表明环境因素会大大影响糖尿病的风险。如果妻子患有糖尿病,则为60(95%CI:1.56-1.64),如果丈​​夫患有糖尿病,则为1.41(95%CI:1.38-1.44)。对仅接受胰岛素治疗的个体进行的亚组分析(N = 23,054)显示出相似的风险模式,尽管其风险估计值略高。结论/解释糖尿病的家庭聚集与遗传倾向有关,而孕产妇的状况是主要因素。此外,我们观察到二级亲属以及无亲属之间的患糖尿病的风险增加,这表明环境因素会大大影响糖尿病的风险。如果妻子患有糖尿病,则为60(95%CI:1.56-1.64),如果丈​​夫患有糖尿病,则为1.41(95%CI:1.38-1.44)。对仅接受胰岛素治疗的个体进行的亚组分析(N = 23,054)显示出相似的风险模式,尽管其风险估计值略高。结论/解释糖尿病的家庭聚集与遗传倾向有关,而孕产妇的状况是主要因素。此外,我们观察到二级亲属以及无亲属之间的患糖尿病的风险增加,这表明环境因素会大大影响糖尿病的风险。尽管风险估算略高。结论/解释糖尿病的家庭聚集与遗传倾向有关,而孕产妇的状况是主要因素。此外,我们观察到二级亲属以及无亲属之间的患糖尿病的风险增加,这表明环境因素会大大影响糖尿病的风险。尽管风险估算略高。结论/解释糖尿病的家庭聚集与遗传倾向有关,而孕产妇的状况是主要因素。此外,我们观察到二级亲属以及不相关配偶之间患糖尿病的风险增加,这表明环境因素会大大影响糖尿病的风险。
更新日期:2020-01-01
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