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Cycle Training improves vascular function and neuropathic symptoms in patients with type 2 diabetes and peripheral neuropathy: A randomized controlled trial.
Experimental Gerontology ( IF 3.9 ) Pub Date : 2019-12-31 , DOI: 10.1016/j.exger.2019.110799
Farhad Gholami 1 , Hamieh Nazari 1 , Milad Alimi 2
Affiliation  

Diabetic peripheral neuropathy (DPN) is associated with peripheral arterial disease and endothelial dysfunction. We investigated the effect of exercise training on the measures of superficial femoral artery (SFA) and neuropathic symptoms in patients with DPN. In a randomized-controlled trial, 31 volunteers with established DPN were randomly assigned to experimental or control groups. Experimental group performed cycling exercise training (50%-70% of heart rate reserve, 30-45 min, 3 sessions/week) over 12 weeks. Before and 48 h after the experimental period a 5-min flow mediated dilation (FMD) response in SFA using Color Doppler Ultrasonography, fasting glucose level, HbA1c and neuropathic score were assessed. FMD% significantly increased in the experimental group (from 3.2 ± 1.1% to 5.7 ± 1.2%) compared to the control condition (P = 0.0001). However, no significant alteration occurred in baseline membrane diameter and intima media thickness (P > 0.05). We also observed a significant improvement in fasting glucose, HbA1c and Michigan Diabetic Neuropathy Score (MDNS) following exercise intervention (all P < 0.05). Linear regression analysis indicated that the change in MDNS was significantly associated with the change in HbA1c (R Square = 0.34, standardized coefficients Beta = -0.58, P = .001) and FMD (R Square = 0.37, standardized coefficients Beta = 0.61, P = .001). This finding may be clinically of considerable importance as metabolic and vascular factors have been indicated to be involved in the development of DPN.

中文翻译:

周期训练可改善2型糖尿病和周围神经病患者的血管功能和神经病性症状:一项随机对照试验。

糖尿病性周围神经病(DPN)与周围动脉疾病和内皮功能障碍有关。我们调查了运动训练对DPN患者股浅动脉(SFA)和神经病变症状的影响。在一项随机对照试验中,将31名已建立DPN的志愿者随机分配到实验组或对照组。实验组在12周内进行了循环运动训练(心率储备的50%-70%,30-45分钟,每周3节)。在实验期之前和之后48小时,使用彩色多普勒超声检查,空腹血糖水平,HbA1c和神经病变评分评估了SFA中5分钟的血流介导的扩张(FMD)反应。与对照组相比,实验组的FMD%显着增加(从3.2±1.1%增至5.7±1.2%)(P = 0.0001)。然而,基线膜直径和内膜中层厚度均未发生明显变化(P> 0.05)。我们还观察到运动干预后的空腹血糖,HbA1c和密歇根糖尿病神经病变评分(MDNS)均有显着改善(所有P <0.05)。线性回归分析表明,MDNS的变化与HbA1c(R Square = 0.34,标准化系数Beta = -0.58,P = .001)和FMD(R Square = 0.37,标准化系数Beta = 0.61,P)显着相关。 = .001)。该发现在临床上可能具有相当重要的意义,因为已经表明代谢和血管因子参与了DPN的发展。我们还观察到运动干预后的空腹血糖,HbA1c和密歇根糖尿病神经病变评分(MDNS)均有显着改善(所有P <0.05)。线性回归分析表明,MDNS的变化与HbA1c(R Square = 0.34,标准化系数Beta = -0.58,P = .001)和FMD(R Square = 0.37,标准化系数Beta = 0.61,P)显着相关。 = .001)。该发现在临床上可能具有相当重要的意义,因为已经表明代谢和血管因子参与了DPN的发展。我们还观察到运动干预后的空腹血糖,HbA1c和密歇根糖尿病神经病变评分(MDNS)均有显着改善(所有P <0.05)。线性回归分析表明,MDNS的变化与HbA1c(R Square = 0.34,标准化系数Beta = -0.58,P = .001)和FMD(R Square = 0.37,标准化系数Beta = 0.61,P)显着相关。 = .001)。该发现在临床上可能具有相当重要的意义,因为已经表明代谢和血管因子参与了DPN的发展。58,P = .001)和FMD(R Square = 0.37,标准化系数Beta = 0.61,P = .001)。该发现在临床上可能具有相当重要的意义,因为已经表明代谢和血管因子参与了DPN的发展。58,P = .001)和FMD(R Square = 0.37,标准化系数Beta = 0.61,P = .001)。该发现在临床上可能具有相当重要的意义,因为已经表明代谢和血管因子参与了DPN的发展。
更新日期:2019-12-31
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