Abstract Some of the respiratory viral infections in chickens pose a significant threat to the poultry industry and public health. In response to viral infections, host innate responses provide the first line of defense against viruses, which often act even before the establishment of the infection. Host cells sense the presence of viral components through germinal encoded pattern recognition receptors (PRRs). The engagement of PRRs with pathogen-associated molecular patterns leads to the induction of pro-inflammatory and interferon productions. Induced antiviral responses play a critical role in the outcome of the infections. In order to improve current strategies for control of viral infections or to advance new strategies aimed against viral infections, a deep understanding of host-virus interaction and induction of antiviral responses is required. In this review, we summarized recent progress in understanding innate antiviral responses in chickens with a focus on the avian influenza virus and infectious bronchitis virus.

中文翻译：

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鸡呼吸道感染的抗病毒反应：重点关注禽流感病毒和传染性支气管炎病毒

摘要 鸡的一些呼吸道病毒感染对家禽业和公众健康构成重大威胁。为应对病毒感染，宿主先天反应提供了抵御病毒的第一道防线，病毒通常甚至在感染建立之前就开始起作用。宿主细胞通过生发编码模式识别受体 (PRR) 感知病毒成分的存在。PRRs 与病原体相关分子模式的结合导致促炎和干扰素的产生。诱导的抗病毒反应在感染结果中起着关键作用。为了改进当前控制病毒感染的策略或推进针对病毒感染的新策略，需要深入了解宿主与病毒的相互作用和抗病毒反应的诱导。在这篇综述中，我们总结了最近在了解鸡的先天抗病毒反应方面取得的进展，重点是禽流感病毒和传染性支气管炎病毒。