Thyroid dysfunction is more frequent in postmenopause and metabolic syndrome characterized by increased proinflammatory cytokines (IL-1, IL-6, TNFα), insulin resistance and overweight. Serum levels of monocyte chemoattractant protein-1 (MCP-1) chemokine and nerve growth factor-β (NGF-β) and their effects were studied on thyroid hormone levels in 133 Hungarian women (postmenopausal 66, obese 32, control 35). MCP-1 and NGF-β levels were measured with enzyme-linked, and thyroid hormones with chemiluminescence immunoassays. Subclinical hypothyroidism in postmenopause (7/66 vs 1/32 cases) and the presence of low FT4 levels in obese women were more frequent (6/32 vs 2/66 cases, p < 0.0447). Obese women showed reduced serum FT4 and higher MCP-1 or NGF-β levels compared to those in postmenopausal women [geometric mean (95%CI): 13.6 (10.9-21.69) vs 15.37 (9.06-20.42) pmol/l, p < 0.003 for FT4, and 19.36 (14.27-26.26) vs 17.29 (12.65-23.63) ng/ml, p < 0.0013 for MCP-1 or 18.64 (6.8-51.11) vs 14.01 (8.59-22.83) ng/ml, p < 0.0003 for NGF-β]. Serum FT4 levels inversely associated with MCP-1 (p < 0.0023, r = -0.1971) or estradiol levels (p < 0.0286, r = -0.1913), and positively associated with age (p < 0.0175, r = 0.2058). As opposed to estradiol and NGF-β levels, BMI had no effects on serum FT4 levels in postmenopausal and obese women forming 3 subgroups displaying only MCP-1, both MCP-1 and NGF-β positivities or no positivities at all. In summary, not only proinflammatory cytokines, but also MCP-1 chemokine and NGF-β levels can play a role in reduced serum FT4 levels in postmenopausal and obese women. Particularly, the decreased FT4 levels were connected to both increased MCP-1 and NGF-β levels in obese women.

中文翻译：

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在匈牙利绝经后和肥胖妇女中研究甲状腺激素 (FT4)、趋化因子 (MCP-1) 和神经营养因子 (NGF-β) 水平之间的相互作用

甲状腺功能障碍在绝经后和代谢综合征中更常见，其特征是促炎细胞因子（IL-1、IL-6、TNFα）增加、胰岛素抵抗和超重。研究了单核细胞趋化蛋白-1 (MCP-1) 趋化因子和神经生长因子-β (NGF-β) 的血清水平及其对 133 名匈牙利妇女（绝经后 66 名，肥胖 32 名，对照组 35 名）甲状腺激素水平的影响。MCP-1 和 NGF-β 水平用酶联法测定，甲状腺激素用化学发光免疫测定法测定。绝经后亚临床甲状腺功能减退症（7/66 对 1/32 例）和肥胖女性中低 FT4 水平的出现更为常见（6/32 对 2/66 例，p < 0.0447）。与绝经后女性相比，肥胖女性的血清 FT4 降低，MCP-1 或 NGF-β 水平升高 [几何平均值 (95%CI)：13.6 (10.9-21.69) 与 15。37 (9.06-20.42) pmol/l，FT4 p < 0.003，19.36 (14.27-26.26) 与 17.29 (12.65-23.63) ng/ml，p < 0.0013 for MCP-1 或 615-18.18.18. (8.59-22.83) ng/ml，对于 NGF-β，p < 0.0003]。血清 FT4 水平与 MCP-1（p < 0.0023，r = -0.1971）或雌二醇水平（p < 0.0286，r = -0.1913）呈负相关，与年龄呈正相关（p < 0.0175，r = 0.2058）。与雌二醇和 NGF-β 水平相反，BMI 对绝经后和肥胖女性的血清 FT4 水平没有影响，形成仅显示 MCP-1、MCP-1 和 NGF-β 阳性或根本没有阳性的 3 个亚组。总之，不仅促炎细胞因子，而且 MCP-1 趋化因子和 NGF-β 水平都可以在绝经后和肥胖女性血清 FT4 水平降低中发挥作用。特别是，