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Stereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase.
Journal of the American Chemical Society ( IF 14.612 ) Pub Date : 2020-01-14 , DOI: 10.1021/jacs.9b10961
Xiao-Lu Li,Lu-Ping Chi,Armando Navarro-Vázquez,Songhwan Hwang,Peter Schmieder,Xiao-Ming Li,Xin Li,Sui-Qun Yang,Xinxiang Lei,Bin-Gui Wang,Han Sun

Determination of the stereochemistry of organic molecules still represents one of the major obstacles in the structure elucidation procedure in drug discovery. Although the application of residual dipolar couplings (RDCs) has revolutionized this field, residual chemical shift anisotropies (RCSAs) which contain valuable structural information for nonprotonated carbons have only been scarcely employed so far. In this study, we present a simple but highly effective solution to extract RCSAs of the analytes in a liquid crystalline phase formed by AAKLVFF oligopeptides. This method does not require any special instruments, devices, or correction during postacquisition data analysis and thus can be easily applied in any chemistry laboratory. To illustrate the potential of this method, the relative configurations of four known natural products (1-4) belonging to different structural classes were confirmed. Moreover, we unambiguously elucidated the stereochemistry of spiroepicoccin A (5), a rare thiodiketopiperazine marine natural product whose configuration could not be assigned based on conventional NMR methods.
更新日期:2020-01-14

 

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