In early childhood, individuals with Prader‐Willi syndrome (PWS) experience excess weight gain and severe hyperphagia with food compulsivity, which often leads to early onset morbid obesity. Effective treatments for appetite suppression and weight control are currently unavailable for PWS. Our aim to further understand the pathogenesis of PWS led us to carry out a comprehensive search of the current and emerging therapies for managing hyperphagia and extreme weight gain in PWS. A literature search was performed using PubMed and the following keywords: “PWS” AND “therapy” OR “[drug name]”; reference lists, pharmaceutical websites, and the ClinicalTrials.gov registry were also reviewed. Articles presenting data from current standard treatments in PWS and also clinical trials of pharmacological agents in the pipeline were selected. Current standard treatments include dietary restriction/modifications, exercise, and growth hormone replacement, which appear to have limited efficacy for appetite and weight control in patients with PWS. The long‐term safety and effectiveness of bariatric surgery in PWS remains unknown. However, many promising pharmacotherapies are in development and, if approved, will bring much needed choices into the PWS pharmacological armamentarium. With the progress that is currently being made in our understanding of PWS, an effective treatment may not be far off.

中文翻译：

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用于治疗普拉德-威利综合征（Prader-Willi syndrome）的食欲亢进和肥胖症的当前和新兴疗法：叙事综述。

在儿童早期，患有Prader-Willi综合征（PWS）的人会出现体重增加过多和严重的食欲亢进以及食物强迫症，这通常会导致早期发病的肥胖症。PWS目前尚无有效的抑制食欲和控制体重的治疗方法。我们进一步了解PWS发病机理的目的使我们对控制PWS吞咽过多和极度增重的当前和新兴疗法进行了全面研究。使用PubMed和以下关键字进行文献检索：“ PWS”和“ therapy”或“ [drug name]”；参考清单，制药网站和ClinicalTrials.gov注册表也进行了审核。选择了一些文章，这些文章提供了来自PWS当前标准治疗方法的数据，以及正在准备中的药理学药物的临床试验。当前的标准治疗方法包括饮食限制/调整，运动和生长激素替代，这些对PWS患者的食欲和体重控制作用似乎有限。PWS减肥手术的长期安全性和有效性仍然未知。但是，许多有前途的药物治疗方法正在开发中，如果获得批准，它将为PWS药理武器库带来许多急需的选择。鉴于我们对PWS的理解目前正在取得进展，有效的治疗方法可能并不遥不可及。许多有前途的药物疗法正在开发中，如果获得批准，它将为PWS药理武器库带来许多急需的选择。鉴于我们对PWS的理解目前正在取得进展，有效的治疗方法可能并不遥不可及。许多有前途的药物疗法正在开发中，如果获得批准，它将为PWS药理武器库带来许多急需的选择。鉴于我们对PWS的理解目前正在取得进展，有效的治疗方法可能并不遥不可及。