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Hazardous effects of urban air particulate matter acute exposure on lung and extrapulmonary organs in mice.
Ecotoxicology and Environmental Safety ( IF 6.8 ) Pub Date : 2019-12-30 , DOI: 10.1016/j.ecoenv.2019.110120
Nadia S Orona 1 , Francisco Astort 1 , Guillermo A Maglione 2 , Sebastian A Ferraro 1 , Maximiliano Martin 3 , Celina Morales 4 , Patricia M Mandalunis 5 , Fernando Brites 3 , Deborah R Tasat 2
Affiliation  

Air particulate matter (PM) can lead to extrapulmonary adverse reactions in organs such as liver and heart either by particle translocation from the lung to the systemic circulation or by the release of lung mediators. Young BALB/c mice were intranasal instilled with 1mg/BW of Urban Air Particles from Buenos Aires or Residual Oil Fly Ash. Histopathology, oxidative metabolism and inflammation on lungs and extrapulmonary organs and the systemic response were evaluated. Lung histophatological analysis supported the rise in the number of inflammatory cells in the bronchoalveolar lavage from PM-exposed animals. Also, both PM caused recruitment of inflammatory cells in the liver and heart parenchyma and IL-6 and transaminases augmentation in serum. We have shown that despite morphochemical differences, both urban air PM altered the lung and extrapulmonary organs. Therefore, exposure to urban air PM may distress body metabolism which, in turn could lead to the development and progression of multifactorial diseases.

中文翻译:

城市空气颗粒物急性暴露对小鼠肺和肺外器官的危害作用。

空气颗粒物(PM)可能通过微粒从肺部转移到全身循环或释放肺介质而导致诸如肝脏和心脏等器官的肺外不良反应。将年轻的BALB / c小鼠鼻内滴入1mg / BW的布宜诺斯艾利斯或残留粉煤灰城市空气颗粒。评价了肺和肺外器官的组织病理学,氧化代谢和炎症以及全身反应。肺组织病理学分析支持暴露于PM的动物支气管肺泡灌洗液中炎症细胞数量的增加。而且,两种PM都会引起肝脏和心脏实质中炎性细胞的募集和IL-6以及血清中转氨酶的增加。我们已经表明,尽管形态化学上的差异,城市空气中的PM都会改变肺和肺外器官。因此,暴露于城市空气中的PM可能会困扰人体代谢,进而导致多因素疾病的发生和发展。
更新日期:2019-12-31
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