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Organochlorine pesticides residue in placenta and their influence on anthropometric measures of infants.
Environmental Research ( IF 8.3 ) Pub Date : 2019-12-31 , DOI: 10.1016/j.envres.2019.109106
M Anand 1 , A Taneja 1
Affiliation  

The objective of this study is to evaluate the influence of placental concentrations of some organochlorine pesticides on newborn's anthropometric measurements (height, weight, head circumference & ponderal index). For this study, we have collected 90 placental tissue samples for the measurement of Dichlorodiphenyltrichloroethane (DDT) & Hexachlocyclohexane (HCH) by Gas Chromatography equipped with Electron Capture Detector (GC-ECD). Regression analysis were performed between outcome variables such as birth weight, birth height, head circumference, ponderal index and independent variable i.e., organochlorine pesticide concentrations. In case of birth weight, there was a substantial decrease of 5.81, 1.94, 4.71, and 2.64 g for 1 ppb (μg/L) increase in placental α-HCH, β-HCH, γ-HCH, and total HCH concentrations respectively. Significant decrease of 2.02 and 0.43 kg/m3 in ponderal index was found with 1 μg/L increase of total-HCH and total DDT concentrations in placenta. The results of this study support an association between environmental exposure to organochlorine pesticides and anthropometric development of the fetus leading to a significant reduction in its birth weight and ponderal index, slight and non-significant reduction in birth height and head circumference. Efforts should be made to reduce exposure of women of reproductive age in relation to long-term impact on health.

中文翻译:

胎盘中有机氯农药残留及其对婴儿人体测量的影响。

这项研究的目的是评估某些有机氯农药的胎盘浓度对新生儿人体测量值(身高,体重,头围和腹部指数)的影响。对于这项研究,我们已经收集了90个胎盘组织样品,用于通过配备电子捕获检测器(GC-ECD)的气相色谱法测量二氯二苯基三氯乙烷(DDT)和六环环己烷(HCH)。在结果变量(如出生体重,出生身高,头围,臀肌指数和自变量,即有机氯农药浓度)之间进行回归分析。对于出生体重,胎盘中的α-HCH,β-HCH,γ-HCH和总HCH浓度分别增加1 ppb(μg/ L),分别显着降低5.81、1.94、4.71和2.64 g。胎盘中总六氯环己烷和滴滴涕的总浓度增加了1μg/ L,则使子宫指数下降了2.02和0.43 kg / m3。这项研究的结果支持环境暴露于有机氯农药与胎儿的人体测量学发展之间的关联,导致胎儿的出生体重和体重指数显着降低,出生身高和头围略有或不显着降低。就长期对健康的影响而言,应努力减少育龄妇女的接触。这项研究的结果支持环境暴露于有机氯农药与胎儿的人体测量学发展之间的关联,导致胎儿的出生体重和体重指数显着降低,出生身高和头围略有或不显着降低。就长期对健康的影响而言,应努力减少育龄妇女的接触。这项研究的结果支持环境暴露于有机氯农药与胎儿的人体测量学发展之间的关联,导致胎儿的出生体重和体重指数显着降低,出生身高和头围略有或不显着降低。就长期对健康的影响而言,应努力减少育龄妇女的接触。
更新日期:2019-12-31
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