Eph (erythropoietin-producing hepatoma) receptors and Ephrin ligands constitute the largest subfamily of receptor tyrosine kinase (RTK), which were first discovered in tumors. Heretofore, Eph protein has been shown to be involved in various tumor biological behaviors including proliferation and progression. The occurrence of specific types of tumor is closely related to the virus infection. Virus entry is a complex process characterized by a series of events. The entry into target cells is an essential step for virus to cause diseases, which requires the fusion of the viral envelope and host cellular membrane mediated by viral glycoproteins and cellular receptors. Integrin molecules are well known as entry receptors for most herpes viruses. However, in recent years, Eph receptors and their Ephrin ligands have been reported to be involved in virus infections. The main mechanism may be the interaction between Eph receptors and conserved viral surface glycoprotein, such as the gH/gL or gB protein of the herpesviridae. This review focuses on the relationship between Eph receptor family and virus infection that summarize the processes of viruses such as EBV, KSHV, HCV, RRV, etc., infecting target cells through Eph receptors and activating its downstream signaling pathways resulting in malignancies. Finally, we discussed the perspectives to block virus infection, prevention, and treatment of viral-related tumors via Eph receptor family.

Eph（产生促红细胞生成素的肝癌）受体和Ephrin配体构成了受体酪氨酸激酶（RTK）的最大亚家族，最早发现于肿瘤中。迄今为止，已经表明Eph蛋白参与多种肿瘤生物学行为，包括增殖和进展。特定类型肿瘤的发生与病毒感染密切相关。病毒进入是一个复杂的过程，具有一系列事件。进入靶细胞是病毒引起疾病的重要步骤，这需要病毒包膜与病毒糖蛋白和细胞受体介导的宿主细胞膜融合。整联蛋白分子是大多数疱疹病毒的进入受体。但是，近年来 据报道，Eph受体及其Ephrin配体与病毒感染有关。主要机制可能是Eph受体与保守的病毒表面糖蛋白（例如疱疹病毒科的gH / gL或gB蛋白）之间的相互作用。这篇综述着重于Eph受体家族与病毒感染之间的关系，总结了诸如EBV，KSHV，HCV，RRV等病毒的过程，通过Eph受体感染靶细胞并激活其下游信号传导途径导致恶性肿瘤。最后，我们讨论了通过Eph受体家族阻断病毒感染，预防和治疗病毒相关肿瘤的观点。这篇综述着重于Eph受体家族与病毒感染之间的关系，总结了诸如EBV，KSHV，HCV，RRV等病毒的过程，通过Eph受体感染靶细胞并激活其下游信号传导途径导致恶性肿瘤。最后，我们讨论了通过Eph受体家族阻断病毒感染，预防和治疗病毒相关肿瘤的观点。这篇综述着重于Eph受体家族与病毒感染之间的关系，总结了诸如EBV，KSHV，HCV，RRV等病毒的过程，通过Eph受体感染靶细胞并激活其下游信号传导途径导致恶性肿瘤。最后，我们讨论了通过Eph受体家族阻断病毒感染，预防和治疗病毒相关肿瘤的观点。