Understanding the mechanisms that underlie age-related macular degeneration (AMD) has led to the identification of key molecules. Hypoxia-inducible transcription factors (HIFs) have been associated with choroidal neovascularization and the progression of AMD into the neovascular clinical phenotype (nAMD). HIFs regulate the expression of multiple growth factors and cytokines involved in angiogenesis and inflammation, hallmarks of nAMD. This knowledge has propelled the development of a new group of therapeutic strategies focused on gene therapy. The present review provides an update on current gene therapies in ocular angiogenesis, particularly nAMD, from both basic and clinical perspectives.

中文翻译：

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缺氧诱导因子在新生血管性年龄相关性黄斑变性中的作用：基因治疗的观点。

了解与年龄有关的黄斑变性（AMD）的基础机制已导致鉴定关键分子。缺氧诱导转录因子（HIFs）与脉络膜新生血管形成和AMD演变为新生血管临床表型（nAMD）有关。HIF调节涉及血管生成和炎症的多种生长因子和细胞因子的表达，这是nAMD的标志。这些知识推动了针对基因治疗的一组新治疗策略的发展。本综述从基础和临床的角度提供了眼血管生成，特别是nAMD中当前基因治疗的最新进展。