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Role of 5-HT7 receptors in the immune system in health and disease
Molecular Medicine ( IF 5.7 ) Pub Date : 2019-12-31 , DOI: 10.1186/s10020-019-0126-x
Alejandro Quintero-Villegas 1, 2 , Sergio Iván Valdés-Ferrer 3, 4, 5
Affiliation  

In mammalians, serotonin (5-HT) has critical roles in the central nervous system (CNS), including mood stability, pain tolerance, or sleep patterns. However, the vast majority of serotonin is produced by intestinal enterochromaffin cells of the gastrointestinal tract and circulating blood platelets, also acting outside of the CNS. Serotonin effects are mediated through its interaction with 5-HT receptors (5-HTRs), a superfamily with a repertoire of at least fourteen well-characterized members. 5-HT7 receptors are the last 5-HTR member to be identified, with well-defined functions in the nervous, gastrointestinal, and vascular systems. The effects of serotonin on the immune response are less well understood. Mast cells are known to produce serotonin, while T cells, dendritic cells, monocytes, macrophages and microglia express 5-HT7 receptor. Here, we review the known roles of 5-HT7 receptors in the immune system, as well as their potential therapeutic implication in inflammatory and immune-mediated disorders.

中文翻译:

5-HT7 受体在免疫系统中在健康和疾病中的作用

在哺乳动物中,血清素 (5-HT) 在中枢神经系统 (CNS) 中具有关键作用,包括情绪稳定性、疼痛耐受性或睡眠模式。然而,绝大多数血清素是由胃肠道的肠嗜铬细胞和循环血小板产生的,也在中枢神经系统之外起作用。5-羟色胺的作用是通过其与 5-HT 受体 (5-HTR) 的相互作用来介导的,5-HTR 是一个拥有至少 14 个特征明确成员的超家族。5-HT7 受体是最后一个被鉴定的 5-HTR 成员,在神经、胃肠道和血管系统中具有明确的功能。血清素对免疫反应的影响还不太清楚。已知肥大细胞产生血清素,而 T 细胞、树突细胞、单核细胞、巨噬细胞和小胶质细胞表达 5-HT7 受体。这里,
更新日期:2019-12-31
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