BACKGROUND To compare the glaucoma diagnostic ability of the ganglion cell-inner plexiform layer (GCIPL) thickness depending on the range around the fovea using wide-angle, swept-source optical coherence tomography (SS-OCT). METHODS We compared the glaucoma diagnostic utility of GCIPL parameters across multiple regions while centered on the fovea. In a wide-angle scan, the GCIPL for each 1-mm2 grid square of a 12 × 9 mm2 scan resulted in 108 data points. With respect to the range of the GCIPL measurements around the macula, the wide-angle scan images were classified into three zones. Zone 1 was defined as a narrow area; zone 2 was defined as a mid-sized area; and zone 3 was defined as a wide area. We recorded the quadrant GCIPL thickness, average, and minimum quadrant GCIPL within each zone. The areas under the receiver operating characteristic (AUROCs) curves were calculated to evaluate the glaucoma diagnostic utility. RESULTS Sixty-one eyes with glaucoma and 59 normal eyes were assessed. The minimum and average GCIPL measurements in zones 1-3 in eyes with glaucoma were significantly lower than those in normal eyes (P <  0.001). The AUROCs for the minimum and inferotemporal GCIPL in zone 1 and the inferotemporal GCIPL thickness in zone 2 were greater than 0.9 (0.945, 0.931, and 0.918, respectively). CONCLUSIONS Wide-angle scanning using SS-OCT will contribute to improvements in the detection of glaucomatous damage. The minimum and inferotemporal GCIPL in zone 1 may be more useful for detecting glaucoma than those in the conventional area.

中文翻译：

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根据中央凹周围的范围比较神经节细胞内丛状层的青光眼诊断能力。

背景技术使用广角扫描源光学相干断层扫描（SS-OCT），根据中央凹周围的范围，比较神经节细胞内丛状层（GCIPL）厚度对青光眼的诊断能力。方法我们比较了以中央凹为中心的多个区域的GCIPL参数的青光眼诊断效用。在广角扫描中，12×9 mm2扫描的每个1-mm2网格正方形的GCIPL得出108个数据点。关于黄斑周围的GCIPL测量范围，将广角扫描图像分为三个区域。1区定义为狭窄区域；2区被定义为中等规模的区域；区域3被定义为一个广阔的区域。我们记录了每个区域内的象限GCIPL厚度，平均值和最小象限GCIPL。计算接收器工作特征（AUROCs）曲线下的面积，以评估青光眼的诊断效用。结果评估了61只患有青光眼的眼和59只正常眼。青光眼眼的1-3区的最小和平均GCIPL测量值显着低于正常眼（P <0.001）。1区的最小和颞下GCIPL的AUROCs和2区的下颞GCIPL的AUROC大于0.9（分别为0.945、0.931和0.918）。结论使用SS-OCT进行的广角扫描将有助于改善青光眼损害的检测。在区域1中的最小和颞下GCIPL可能比常规区域中的GCIPL更有用。结果评估了61只患有青光眼的眼和59只正常眼。青光眼眼的1-3区的最小和平均GCIPL测量值显着低于正常眼（P <0.001）。1区的最小和颞下GCIPL的AUROCs和2区的下颞GCIPL的AUROC大于0.9（分别为0.945、0.931和0.918）。结论使用SS-OCT进行的广角扫描将有助于改善青光眼损害的检测。在区域1中的最小和颞下GCIPL可能比常规区域中的GCIPL更有用。结果评估了61只患有青光眼的眼和59只正常眼。青光眼眼的1-3区的最小和平均GCIPL测量值显着低于正常眼（P <0.001）。1区的最小和颞下GCIPL的AUROCs和2区的下颞GCIPL的AUROC大于0.9（分别为0.945、0.931和0.918）。结论使用SS-OCT进行的广角扫描将有助于改善青光眼损害的检测。在区域1中的最小和颞下GCIPL可能比常规区域中的GCIPL更有用。1区的最小和颞下GCIPL的AUROCs和2区的下颞GCIPL的AUROC大于0.9（分别为0.945、0.931和0.918）。结论使用SS-OCT进行的广角扫描将有助于改善青光眼损害的检测。在区域1中的最小和颞下GCIPL可能比常规区域中的GCIPL更有用。1区的最小和颞下GCIPL的AUROCs和2区的下颞GCIPL的AUROC大于0.9（分别为0.945、0.931和0.918）。结论使用SS-OCT进行的广角扫描将有助于改善青光眼损害的检测。在区域1中的最小和颞下GCIPL可能比常规区域中的GCIPL更有用。