Percutaneous devices are prone to epidermal downgrowth and sinus tract formation, which can serve as a nidus for bacterial colonization and increase the risk of peri‐prosthetic infection. A laser microgrooved topography has been shown to limit gingival epidermal downgrowth around dental implants. However, the efficacy of this laser microgrooved topography to limit epidermal downgrowth around nongingival percutaneous devices is yet to be investigated. In this study, devices with a porous‐coated subdermal component and a percutaneous post were designed and manufactured. The proximal 2 mm section of the percutaneous post were left smooth, or were textured with either a porous coating, or with the laser microgrooved topography. The smooth and porous topographies served as controls. The devices were tested in a hairless guinea pig back model, where 18 animals were randomly assigned into three groups, with each group receiving one implant type (n = 6/group). Four weeks postimplantation, the devices with surrounding soft‐tissues were harvested and processed for histological analyses. Results indicated that the laser microgrooved topography failed to prevent epidermal downgrowth (23 ± 4%) around percutaneous posts in this model. Furthermore, no significant differences (p = 0.70) in epidermal downgrowth were present between the three topographies, with all the groups exhibiting similar measures of downgrowth. Overall, these findings suggest that the laser microgrooved topography may not halt downgrowth around percutaneous devices for dermal applications.

中文翻译：

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评估激光微槽钛经皮装置周围的软组织反应。

经皮装置容易出现表皮向下生长和窦道形成，这可以作为细菌定植的巢穴并增加假体周围感染的风险。激光微槽形貌已被证明可以限制牙种植体周围的牙龈表皮向下生长。然而，这种激光微槽形貌限制非牙龈经皮装置周围表皮向下生长的功效尚待研究。在这项研究中，设计和制造了带有多孔涂层皮下组件和经皮柱的装置。经皮桩的近端 2 mm 部分保持光滑，或带有多孔涂层或激光微槽形貌。光滑多孔的地形用作对照。这些设备在无毛豚鼠背部模型中进行了测试，n = 6/组）。植入后 4 周，收集并处理带有周围软组织的装置以进行组织学分析。结果表明，在该模型中，激光微槽形貌未能阻止经皮柱周围的表皮向下生长 (23 ± 4%)。此外，三种地形之间的表皮向下生长没有显着差异 ( p = 0.70)，所有组都表现出相似的向下生长测量值。总的来说，这些发现表明，激光微槽形貌可能不会阻止用于皮肤应用的经皮设备周围的向下生长。