Supplemental Digital Content is available in the text. Left ventricular hypertrophy is a strong predictor of prognosis in hypertension. Physical activity is associated with higher left ventricular mass but also reduced risk of cardiovascular outcomes. The aims were to explore whether (1) presence of hypertension modifies the association between physical activity and left ventricular mass; (2) the beneficial association between physical activity and prognostic outcome is modified by left ventricular hypertrophy. Randomly selected number of 3078 persons from the general population underwent echocardiogram. Left ventricular mass was indexed to body surface area. Level of physical activity was self-reported: inactivity, light activity, and moderate/high activity. Blood pressure was measured in rest: normal BP (<140/90 mm Hg) and hypertension (≥140/90 mm Hg or in pharmacological treatment for hypertension). Presence of hypertension modified the association between physical activity and left ventricular mass index significantly (test for interaction: P=0.01): in normal BP, higher levels of physical activity were associated with significantly higher left ventricular mass index (P<0.001), but this was not present in hypertension (P=0.90). Level of physical activity was associated with reduction in mortality and cardiovascular outcome independent of the presence of LVH (Persons with LVH: light activity HR, 0.77 [0.52–1.15], moderate/high activity HR, 0.61 [0.38–0.97]; test for interaction between LVH and level of physical activity P=0.71). In conclusion, persons with normal BP had higher left ventricular mass index at increased levels of physical activity, whereas this association was not present among persons with hypertension. Level of physical activity was associated with better prognosis independent of whether left ventricular hypertrophy was present or not.

中文翻译：

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体力活动水平、左心室质量、高血压和预后

补充数字内容在文本中可用。左心室肥厚是高血压预后的强预测因子。体力活动与较高的左心室质量有关，但也降低了心血管结局的风险。目的是探讨（1）高血压的存在是否会改变体力活动与左心室质量之间的关联；(2) 体力活动和预后结果之间的有益关联被左心室肥厚改变。从一般人群中随机选择的 3078 人接受了超声心动图检查。左心室质量与体表面积有关。身体活动水平由自我报告：不活动、轻度活动和中/高活动。静息时测量血压：血压正常（< 140/90 毫米汞柱）和高血压（≥140/90 毫米汞柱或高血压药物治疗）。高血压的存在显着改变了体力活动与左心室质量指数之间的关联（相互作用检验：P=0.01）：在正常血压中，较高水平的体力活动与显着较高的左心室质量指数相关（P<0.001），但这在高血压中不存在（P = 0.90）。体力活动水平与死亡率和心血管结果的降低相关，而与 LVH 的存在无关（LVH 患者：轻度活动 HR，0.77 [0.52-1.15]，中/高活动 HR，0.61 [0.38-0.97]；测试LVH 与体力活动水平之间的相互作用 P=0.71）。总之，血压正常的人在增加体力活动时左心室质量指数较高，而这种关联在高血压患者中不存在。无论是否存在左心室肥厚，体力活动水平与更好的预后相关。