Transmembrane transport is essential and plays critical roles for molecule exchange for cell survival. Methods capable of mimicking and regulating transmembrane transport have transformed the ability to create biosensors, separation membranes, and drug carriers. However, artificial channels have been largely restricted by their complicated chemical fabrication and inefficiency to dynamically manipulate the transport process. Here, a novel approach to regulate transmembrane transport is described by simply adjusting the mechanical deformation of liposomal bilayers which are covalently embedded in a crosslinked hydrogel network. This new approach is able to dynamically control transmembrane transport by stretching and loosening. The transmembrane diffusion of molecules can be switched on and off, and precisely tuned by varying strain. A potential of this method to programmably regulate cell growth is demonstrated by tuning external mechanical force. Given its unique characteristics, this method allows the development of innovative systems for controlled transmembrane transport of molecules.

中文翻译：

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机械变形介导的跨膜运输。

跨膜运输是必不可少的，并且在分子交换以维持细胞存活中起着至关重要的作用。能够模仿和调节跨膜运输的方法已经改变了创建生物传感器，分离膜和药物载体的能力。然而，人工渠道在很大程度上受到其复杂的化学制造过程以及动态操纵运输过程效率低下的限制。这里，通过简单地调节共价嵌入交联的水凝胶网络中的脂质体双层的机械变形来描述调节跨膜运输的新颖方法。这种新方法能够通过拉伸和松弛来动态控制跨膜运输。分子的跨膜扩散可以打开和关闭，并通过变化的应变进行精确调节。通过调节外部机械力证明了该方法可程序性调节细胞生长的潜力。鉴于其独特的特性，该方法允许开发创新的系统来控制分子的跨膜转运。