K+-dependent Na+/Ca2+ exchanger proteins (NCKX1-5) of the SLC24 gene family play important roles in a wide range of biological processes including but not limited to rod and cone photoreceptor vision, olfaction, enamel formation and skin pigmentation. NCKX proteins are also widely expressed throughout the brain and NCKX2 and NCKX4 knockouts in mice have specific phenotypes. Here we review our work on structure-function relationships of NCKX proteins. We discuss membrane topology, domains critical to transport function, and residues critical to cation binding and transport function, all in the context of crystal structures that were obtained for the archaeal Na+/Ca2+ exchanger NCX_Mj.

中文翻译：

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依赖K +的Na + / Ca2 +交换子（NCKX）的结构-功能关系。

SLC24基因家族的K +依赖性Na + / Ca2 +交换蛋白（NCKX1-5）在广泛的生物学过程中起重要作用，包括但不限于视杆和视锥感光器视觉，嗅觉，牙釉质形成和皮肤色素沉着。NCKX蛋白也广泛表达在整个大脑中，小鼠中的NCKX2和NCKX4基因敲除具有特定的表型。在这里，我们回顾我们在NCKX蛋白质的结构-功能关系上的工作。我们讨论了膜拓扑结构，对转运功能至关重要的结构域以及对阳离子结合和转运功能至关重要的残基，所有这些都在为古细菌Na + / Ca2 +交换剂NCX_Mj获得的晶体结构的背景下进行。