The Staudinger reduction provides a bio‐orthogonal and generalizable approach to small‐molecule‐triggered protein activation. We have developed three genetically encoded caged lysine analogues that can be rapidly activated with phosphines in order to control protein function in mammalian cells. This was applied to the conditional control of protein translocation and triggering SUMOylation, an important post‐translational modification, of a caged target protein. More information can be found in the full paper by A. Deiters et al.

中文翻译：

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膦活化的赖氨酸类似物可快速化学控制蛋白质亚细胞定位和蛋白质SUMOylation

施陶丁格还原法为小分子触发的蛋白质活化提供了一种生物正交且可推广的方法。我们已经开发了三种基因编码的笼状赖氨酸类似物，可以用膦快速激活它们，以控制哺乳动物细胞中的蛋白质功能。这被用于蛋白质转运的条件控制和触发笼状靶蛋白的SUMOylation（重要的翻译后修饰）。更多信息可以在A. Deiters等人的全文中找到。