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Characteristics of bone turnover markers in women with gestational diabetes mellitus.
Clinical Biochemistry ( IF 2.8 ) Pub Date : 2019-12-30 , DOI: 10.1016/j.clinbiochem.2019.12.013
Jing Zhang 1 , Yiduo Zhang 1 , Jing Wang 2 , Fan Yu 1
Affiliation  

BACKGROUND Bone turnover markers (BTMs) can be applied to the assessment of bone formation and bone resorption activity. The aim of this study was to investigate the changes in BTMs in women with gestational diabetes mellitus (GDM). METHODS One hundred and five women with gestational diabetes mellitus defined as the GDM group and 46 healthy pregnant women with normal glucose tolerance selected as the control group were enrolled in this study. Serum samples were collected during regular obstetric examinations and the serum levels of total procollagen type 1 N-terminal propeptide (P1NP), N-terminal midfragment of osteocalcin (N-MID), and β-C-terminal telopeptide of type 1 collagen (β-CTX) were measured. An independent-sample t-test, the Mann-Whitney U test, and a Pearson correlation analysis were performed for data analyses. RESULTS Serum β-CTX levels in the GDM group were significantly higher than those in the control group (296.00 [235.00-369.00] pg/mL vs. 218.5 [165.25-292.50] pg/mL, p < 0.05), while P1NP and N-MID levels did not differ between the two groups. The Pearson correlation analysis revealed that β-CTX level was correlated with blood glucose level. CONCLUSIONS The difference in β-CTX levels indicated that bone resorption in patients with GDM diabetes was higher than that in pregnant women with normal glucose tolerance. No obvious differences in bone formation markers P1NP and N-MID were found between the two groups.

中文翻译:

妊娠糖尿病妇女骨转换标志物的特征。

背景技术骨转换标记物(BTM)可用于评估骨形成和骨吸收活性。这项研究的目的是调查妊娠糖尿病(GDM)妇女的BTM的变化。方法选择105例妊娠糖尿病妇女作为GDM组,将46例糖耐量正常的健康孕妇作为对照组。在常规产科检查期间收集血清样本,并检测血清总胶原蛋白的1型N末端前肽(P1NP),骨钙素的N末端中段(N-MID)和1型胶原的β-C末端端肽(β -CTX)。进行了独立样本t检验,Mann-Whitney U检验和Pearson相关分析,以进行数据分析。结果GDM组的血清β-CTX水平显着高于对照组(296.00 [235.00-369.00] pg / mL,而218.5 [165.25-292.50] pg / mL,p <0.05),而P1NP和N两组之间的-MID水平没有差异。皮尔逊相关分析显示,β-CTX水平与血糖水平相关。结论β-CTX水平的差异表明,GDM糖尿病患者的骨吸收高于正常葡萄糖耐量的孕妇。两组之间的骨形成标志物P1NP和N-MID没有明显差异。皮尔逊相关分析显示,β-CTX水平与血糖水平相关。结论β-CTX水平的差异表明,GDM糖尿病患者的骨吸收高于葡萄糖耐量正常的孕妇。两组之间的骨形成标志物P1NP和N-MID没有明显差异。皮尔逊相关分析显示,β-CTX水平与血糖水平相关。结论β-CTX水平的差异表明,GDM糖尿病患者的骨吸收高于正常葡萄糖耐量的孕妇。两组之间的骨形成标志物P1NP和N-MID没有明显差异。
更新日期:2019-12-30
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