Abstract Leishmaniases are neglected diseases that represent a significant public health concern in several countries. In this study, nickel (II), manganese (II), and palladium (II) coordination compounds with ibuprofen were synthesized, and their potential leishmanicidal activity was evaluated. The compounds were characterized by molar conductimetry, electronics spectroscopy, infrared vibrational spectroscopy, 13C NMR, and elemental analysis, and the data were compared with literature. Comparison of the leishmanicidal activity of these compounds against promastigotes of Leishmania amazonensis and the cytotoxicity against lung fibroblast cells indicated that the IbuNi (nickel ibuprofen complex) compound was promising because it had the highest selectivity index (3.28) compared to the other compounds. In vitro tests on infected macrophages were performed and showed a decrease in infectivity of 31.21% at the concentration of 184.75 μM for the above compound and indicated that IbuPd (palladium ibuprofen complex) was toxic.

中文翻译：

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布洛芬及其与 Ni (II)、Mn(II) 和 Pd(II) 的络合物的杀利什曼原虫活性

摘要 利什曼病是被忽视的疾病，在几个国家代表了重大的公共卫生问题。本研究合成了镍 (II)、锰 (II) 和钯 (II) 与布洛芬的配位化合物，并评估了它们的潜在杀利什曼原虫活性。采用摩尔电导、电子光谱、红外振动光谱、13C核磁共振、元素分析等对化合物进行表征，并与文献进行数据比较。比较这些化合物对亚马逊利什曼原虫的前鞭毛体的杀利什曼原虫活性和对肺成纤维细胞的细胞毒性表明，IbuNi（镍布洛芬复合物）化合物是有希望的，因为与其他化合物相比，它具有最高的选择性指数（3.28）。