A new 2-arylbenzofuran, sesbagrandiflorain C (1), together with four known compounds, 2-(3,4-dihydroxy-2-methoxyphenyl)-4-hydroxy-6-methoxybenzofuran-3-carbaldehyde (2), 2-(4-hydroxy-2-methoxyphenyl)-5,6-dimethoxybenzofuran-3-carboxaldehyde (3), sesbagrandiflorain A (4) and sesbagrandiflorain B (5), have been isolated from the stem bark of an Indonesian plant, Sesbania grandiflora (L.) Pers. The chemical structure of compound 1 was elucidated by UV, IR, MS, and NMR spectroscopic techniques. The proton and carbon NMR resonances of 1 were also compared with the predicted chemical shifts obtained from DFT quantum mechanical calculations with Gaussian. None of the compounds showed antibacterial activity against Bacillus subtilis, Escherichia coli, Mycobacterium smegmatis, Pseudomonas aeruginosa, and Staphylococcus aureus in an agar diffusion assay. However, sesbagrandiflorains A (4) and B (5) exhibited moderate activity against Mycobacterium tuberculosis H37Rv. In addition, compounds 1 – 5 have moderate cytotoxicity against HeLa, HepG2, and MCF-7 cancer cell lines.

一种新的2-芳基苯并呋喃sesbagrandiflorain C（1）与四个已知化合物2-（3,4-二羟基-2-甲氧基苯基）-4-羟基-6-甲氧基苯并呋喃-3-甲醛（2），2-（从印度尼西亚植物大叶Se（Sesbania grandiflora（L）的茎皮中分离出4-羟基-2-甲氧基苯基）-5,6-二甲氧基苯并呋喃-3-羧醛（3），sesbagrandiflorain A（4）和sesbagrandiflorain B（5）。。）个人。通过UV，IR，MS和NMR光谱技术阐明了化合物1的化学结构。的质子和碳NMR共振1还与通过高斯DFT量子力学计算获得的预测化学位移进行了比较。在琼脂扩散试验中，没有一种化合物对枯草芽孢杆菌，大肠杆菌，耻垢分枝杆菌，铜绿假单胞菌和金黄色葡萄球菌显示出抗菌活性。然而，sesbagrandiflorains A（4）和B（5）对结核分枝杆菌H37Rv表现出中等活性。此外，化合物1 - 5具有抵抗的HeLa，HepG2细胞，和MCF-7癌细胞系的细胞毒性适中。