BACKGROUND Hypertension is a highly prevalent disease and the leading cause of chronic kidney disease (CKD). Metabolic syndrome could also be the risk factor for CKD. We sought to study the association between metabolic syndrome components and the prevalence of CKD in patients with hypertension. METHODS We carried out a multi-center cross-sectional study from Apr. 2017- Apr. 2018 in 15 cities in China. RESULTS A total of 2484 patients with hypertension were enrolled. Among them, 56% were male and the average age was 65.12 ± 12.71 years. The systolic BP/diastolic BP was 142 ± 18/83 ± 12 mmHg. Metabolic syndrome components turned out to be highly prevalent in patients with hypertension, ranging from 40 to 58%. The prevalence of chronic kidney disease reached 22.0%. Multi-variate logistic analysis revealed that elevated triglyceride (TG) (OR = 1.81, 95% CI 1.28-2.57, p < 0.01), elevated fasting blood glucose (FBG) (OR = 1.43, 95% CI 1.00-2.07, p = 0.05) and hypertension grades (OR = 1.20, 95% CI 1.00-1.44, p = 0.05) were associated with the prevalence of CKD. In sub-group analysis, elevated TG remained strongly associated with CKD in both diabetes (OR = 2.10, 95%CI 1.22-3.61, p < 0.01) and non-diabetes (OR = 1.53, 95% CI 1.09-2.16, p = 0.01). In sub-group analysis of hypertension grades, there was also a graded trend between elevated TG and CKD from controlled blood pressure (BP) to hypertension grade 2 (OR = 1.81, 95%CI 1.06-3.11, p = 0.03; OR = 1.85, 95%CI 1.00-3.43, p = 0.05; OR = 2.81, 95% CI 1.09-7.28, p = 0.03, respectively). CONCLUSION Elevated TG, elevated FBG and hypertension grades were significantly associated with the prevalence of CKD in patients with hypertension. Particularly, elevated TG was strongly associated with CKD, independent of diabetes and hypertension grades.

中文翻译：

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高血压患者代谢综合征成分与慢性肾脏疾病的关系。

背景技术高血压是高度流行的疾病，并且是慢性肾脏疾病（CKD）的主要原因。代谢综合症也可能是CKD的危险因素。我们试图研究高血压患者代谢综合征成分与CKD患病率之间的关系。方法我们于2017年4月至2018年4月在中​​国15个城市进行了多中心横断面研究。结果总共招募了2484例高血压患者。其中，男性占56％，平均年龄为65.12±12.71岁。收缩压/舒张压为142±18/83±12mmHg。事实证明，代谢综合征的成分在高血压患者中非常普遍，占40％至58％。慢性肾脏病的患病率达到22.0％。多元逻辑分析显示甘油三酸酯（TG）升高（OR = 1.81，95％CI 1.28-2.57，p <0.01），空腹血糖（FBG）升高（OR = 1.43，95％CI 1.00-2.07，p = 0.05）和高血压等级（OR = 1.20，95％CI 1.00-1.44， p = 0.05）与CKD的患病率相关。在亚组分析中，在糖尿病（OR = 2.10，95％CI 1.22-3.61，p <0.01）和非糖尿病（OR = 1.53，95％CI 1.09-2.16，p = 0.01）。在高血压等级的亚组分析中，TG和CKD升高之间也存在从控制血压（BP）到2级高血压的分级趋势（OR = 1.81，95％CI 1.06-3.11，p = 0.03; OR = 1.85 ，95％CI 1.00-3.43，p = 0.05； OR = 2.81，95％CI 1.09-7.28，p = 0.03）。结论高血压患者的TG升高，FBG升高和高血压等级与CKD的患病率显着相关。