BACKGROUND To study the outcomes and experiences of using metallic stents in treating patients with malignant ureteral obstruction (MUO), we examined the effects of metallic ureteral stenting using the Cook Resonance® stent in the treatment of MUO. METHODS All patients who had a Resonance metallic stent inserted between April 2015 and March 2018 at one of multiple facilities were prospectively observed with a 1-year follow-up. The primary outcome was the patency rate of the metallic ureteral stent. The secondary outcomes included the complications (e.g., infection and fever). RESULTS Although stent insertion was attempted in 50 patients, the stent could not be inserted as a ureteral stent in three patients due to severe ureteral stricture, and one ureteral cancer patient was excluded from the analysis. The remaining 46 patients' median age was 67 years (range 28-85 years) (16 males, 30 females). Twenty-four patients died during the study; their median survival time was 226 days. The median follow-up period for the censored patients was 355 days (range 16-372 days), and just seven patients were still alive without Resonance failure > 1 year later. The women's IPSS scores tended to be lower than those of the men. Regarding the OABSS score, although the women's total score tended to be low, the difference between the men's and women's scores was nonsignificant. The bacteria detected from urine culture after stent insertion were more gram-positive than gram-negative. CONCLUSION Metallic ureteric stenting using the Resonance stent is safe and effective for treating MUO. Subjective symptoms were relatively less in the female patients.

中文翻译：

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共振®金属输尿管支架在恶性输尿管梗阻的治疗中：一项前瞻性观察研究。

背景技术为了研究使用金属支架治疗恶性输尿管梗阻（MUO）患者的结果和经验，我们检查了使用CookResonance®支架对金属输尿管支架治疗MUO的效果。方法前瞻性观察2015年4月至2018年3月之间在多个设施之一中插入Resonance金属支架的所有患者，并进行了为期1年的随访。主要结果是输尿管金属支架的通畅率。次要结果包括并发症（例如感染和发烧）。结果尽管有50例患者尝试插入支架，但由于严重的输尿管狭窄，有3例患者无法将其作为输尿管支架插入，分析中排除了一名输尿管癌患者。其余46例 中位年龄为67岁（年龄在28-85岁之间）（男16例，女30例）。研究期间有24名患者死亡。他们的中位生存时间为226天。接受检查的患者的中位随访期为355天（范围16-372天），只有7位患者存活，且共振失败> 1年后。女性的IPSS得分往往低于男性。关于OABSS分数，尽管女性的总得分趋于低下，但是男性和女性的得分之间的差异并不显着。支架插入后从尿液培养物中检测到的细菌比革兰氏阴性菌更具有革兰氏阳性菌。结论使用Resonance支架进行金属输尿管支架置入术治疗MUO是安全有效的。女性患者的主观症状相对较少。