BACKGROUND Acute myocardial infarction (AMI) alters left ventricular (LV) hemodynamics, resulting in decreased global LV ejection fraction and global LV kinetic energy. We hypothesize that anterior AMI effects localized alterations in LV flow and developed a regional approach to analyze these local changes with 4D flow MRI. METHODS 4D flow cardiac magnetic resonance (CMR) data was compared between 12 anterior AMI patients (11 males; 66 ± 12yo; prospectively acquired in 2016-2017) and 19 healthy volunteers (10 males; 40 ± 16yo; retrospective from 2010 to 2011 study). The LV cavity was contoured on short axis cine steady-state free procession CMR and partitioned into three regions: base, mid-ventricle, and apex. 4D flow data was registered to the short axis segmentation. Peak systolic and diastolic through-plane flows were compared region-by-region between groups using linear models of flow with age, sex, and heart rate as covariates. RESULTS Peak systolic flow was reduced in anterior AMI subjects compared to controls in the LV mid-ventricle (fitted reduction = 3.9 L/min; P = 0.01) and apex (fitted reduction = 1.4 L/min; P = 0.02). Peak diastolic flow was also lower in anterior AMI subjects compared to controls in the apex (fitted reduction = 2.4 L/min; P = 0.01). CONCLUSIONS A regional method to analyze 4D LV flow data was applied in anterior AMI patients and controls. Anterior AMI patients had reduced regional flow relative to controls.

中文翻译：

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前壁急性心肌梗死后左心室局部血流减少：使用 4D 血流 MRI 的病例对照研究。

背景急性心肌梗死 (AMI) 改变左心室 (LV) 血流动力学，导致整体 LV 射血分数和整体 LV 动能降低。我们假设前壁 AMI 会影响 LV 血流的局部变化，并开发了一种区域方法来分析这些局部变化与 4D 血流 MRI。方法 比较 12 名前壁 AMI 患者（11 名男性；66±12 岁；2016-2017 年前瞻性获得）和 19 名健康志愿者（10 名男性；40±16 岁；2010 年至 2011 年回顾性研究）之间的 4D 流动心脏磁共振 (CMR) 数据）。LV 腔在短轴电影稳态自由行 CMR 上绘制轮廓并分为三个区域：基部、中心室和心尖部。4D 流数据注册到短轴分割。使用以年龄、性别和心率作为协变量的线性流量模型，逐个区域地比较了通过平面的收缩和舒张峰值流量。结果 与左心室中心室（拟合减量 = 3.9 L/min；P = 0.01）和心尖（拟合减量 = 1.4 L/min；P = 0.02）的对照组相比，前壁 AMI 受试者的峰值收缩流量降低。与心尖中的对照相比，前壁 AMI 受试者的舒张期峰值流量也较低（拟合减少 = 2.4 L/min；P = 0.01）。结论 分析 4D LV 血流数据的区域方法适用于前壁 AMI 患者和对照组。与对照组相比，前壁 AMI 患者的局部血流减少。结果 与左心室中心室（拟合减量 = 3.9 L/min；P = 0.01）和心尖（拟合减量 = 1.4 L/min；P = 0.02）的对照组相比，前壁 AMI 受试者的峰值收缩流量降低。与心尖中的对照相比，前壁 AMI 受试者的舒张期峰值流量也较低（拟合减少 = 2.4 L/min；P = 0.01）。结论 分析 4D LV 血流数据的区域方法适用于前壁 AMI 患者和对照组。与对照组相比，前壁 AMI 患者的局部血流减少。结果 与左心室中心室（拟合减量 = 3.9 L/min；P = 0.01）和心尖（拟合减量 = 1.4 L/min；P = 0.02）的对照组相比，前壁 AMI 受试者的峰值收缩流量降低。与心尖中的对照相比，前壁 AMI 受试者的舒张期峰值流量也较低（拟合减少 = 2.4 L/min；P = 0.01）。结论 分析 4D LV 血流数据的区域方法适用于前壁 AMI 患者和对照组。与对照组相比，前壁 AMI 患者的局部血流减少。结论 分析 4D LV 血流数据的区域方法适用于前壁 AMI 患者和对照组。与对照组相比，前壁 AMI 患者的局部血流减少。结论 分析 4D LV 血流数据的区域方法适用于前壁 AMI 患者和对照组。与对照组相比，前壁 AMI 患者的局部血流减少。