Background and Purpose- Stroke is the leading cause of disability in United States, and aphasia is a common sequela after a left hemisphere stroke. Functional imaging and brain stimulation studies show that right hemisphere structures are detrimental to aphasia recovery but evidence from diffusion tensor imaging is lacking. We investigated the role of homologous language pathways in naming recovery after left hemispheric stroke. Methods- Patients with aphasia after a left hemispheric stroke underwent naming assessment using the Boston Naming Test and diffusion tensor imaging at the acute and chronic time points. We analyzed diffusion tensor imaging of right arcuate fasciculus and frontal aslant tracts. We used Wilcoxon rank-sum test to evaluate structural lateralization patterns and partial Spearman correlation/multivariate generalized linear model to determine the role of right arcuate fasciculus and frontal aslant tracts in naming recovery after controlling for confounders. Results were corrected for multiple comparisons. Results- On average, the structural integrity of left language pathways deteriorated more than their right homologs, such that there was rightward lateralization in the chronic stage. Regression/correlation analyses showed that greater preservation of tract integrity of right arcuate fasciculus was associated with poorer naming recovery. Conclusions- Our study provides preliminary evidence that preservation of right homologs of language pathways is associated with poor recovery of naming after a left hemispheric stroke, consistent with previous evidence that maintaining greater reliance on left hemisphere structures is associated with better language recovery.

中文翻译：

---

右半球同源语言通路负面预测笔画后的命名恢复。

背景和目的中风是美国残疾的主要原因，失语症是左半球中风后的常见后遗症。功能成像和大脑刺激研究表明，右半球结构不利于失语症的恢复，但缺乏弥散张量成像的证据。我们调查了同源语言通路在左半球卒中后命名恢复中的作用。方法-左半球卒中后失语症患者使用波士顿命名测试和弥散张量成像在急性和慢性时间点进行命名评估。我们分析了右弓形筋膜和额叶斜道的弥散张量成像。我们使用Wilcoxon秩和检验来评估结构横向化模式和部分Spearman相关/多元广义线性模型，以确定控制混杂因素后，右弓形筋膜和额叶斜道在命名恢复中的作用。对结果进行了校正，以进行多次比较。结果-平均而言，左语言通路的结构完整性比其右同源物恶化得更多，以致于在慢性阶段有向右偏侧化。回归/相关分析表明，右弓形束的束完整性得到更大程度的保留与命名恢复较差有关。结论-我们的研究提供了初步的证据，表明保留语言通路的正确同源物与左半球卒中后命名恢复不佳有关，