Understanding the complexity of T cell subsets and their role in disease has been a continuing effort. In 2019, the field saw a number of important advances in identifying new T cell subsets and functional states associated with immunopathology, described molecular mechanisms involved in T cell dysregulation in infection and cancer, and provided insight into what defines a healthy T cell state. In this Year in Review, Donna Farber discusses some of the exciting breakthroughs that occurred in the T cell field in 2019, highlighting the therapeutic implications for our understanding of T cell function in infection, allergy, inflammatory disease and cancer.

中文翻译：

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T细胞在健康和疾病中的形式和功能。

理解T细胞亚群的复杂性及其在疾病中的作用一直是一项持续的工作。在2019年，该领域在识别与免疫病理学相关的新T细胞亚群和功能状态方面取得了许多重要进展，描述了感染和癌症中T细胞失调所涉及的分子机制，并为定义健康T细胞状态提供了见识。在本年度回顾中，唐娜·法伯（Donna Farber）讨论了2019年T细胞领域发生的一些激动人心的突破，强调了对我们对感染，过敏，炎症性疾病和癌症中T细胞功能的理解的治疗意义。