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Boosting the photodynamic therapy efficiency by using stimuli-responsive and AIE-featured nanoparticles.
Biomaterials ( IF 14.0 ) Pub Date : 2019-12-30 , DOI: 10.1016/j.biomaterials.2019.119749
Youmei Li 1 , Qian Wu 1 , Miaomiao Kang 1 , Nan Song 1 , Dong Wang 2 , Ben Zhong Tang 3
Affiliation  

Photosensitizers with aggregation-induced emission (AIE) characteristics are of great interest for cancer theranostics involving both fluorescence imaging and photodynamic therapy (PDT). However, in the purpose of clinical trials of PDT, the development of prominent drug delivery systems for boosting the PDT efficiency of AIE photosensitizers is highly desirable but still remain a challenging task. Herein, a novel strategy is designed and performed for boosting PDT effect based on stimuli-responsive nano-micelles as extraordinary carriers for an AIE photosensitizer, namely MeTTMN. Those presented stimuli-responsive nano-micelles loading MeTTMN exhibit good biocompatibility, excellent stability, appropriate nanoparticle size, high loading efficiency, outstanding imaging quality and significantly promoted PDT performance, eventually making them remarkably impressive and significantly superior to commercially available nano-micelles carried MeTTMN. This study thus offers an ideal template for fluorescence imaging-guided PDT, as well as a promising candidate for clinical trials.

中文翻译:

通过使用刺激响应和具有AIE功能的纳米颗粒,提高光动力疗法的效率。

具有聚集诱导发射(AIE)特性的光敏剂对于涉及荧光成像和光动力疗法(PDT)的癌症治疗学非常感兴趣。但是,出于PDT临床试验的目的,迫切需要开发出显着的药物递送系统以提高AIE光敏剂的PDT效率,但仍然是一项艰巨的任务。本文中,基于刺激响应性纳米胶束作为AIE光敏剂即MeTTMN的非常规载体,设计并执行了用于增强PDT效果的新策略。那些呈现负载MeTTMN的刺激响应性纳米胶束的生物,具有良好的生物相容性,出色的稳定性,合适的纳米颗粒尺寸,高的加载效率,出色的成像质量以及显着提升的PDT性能,最终使它们非常引人注目,并且显着优于市售的带有MeTTMN的纳米胶束。因此,这项研究为荧光成像引导的PDT提供了理想的模板,并为临床试验提供了有希望的候选者。
更新日期:2019-12-30
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