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Correlations Between Human Immunodeficiency Virus (HIV) Infection and Rectal Gonorrhea Incidence in Men Who Have Sex With Men: Implications for Future HIV Preexposure Prophylaxis Trials.
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2020-01-02 , DOI: 10.1093/infdis/jiz037
Charu Mullick 1 , Jeffrey Murray 1
Affiliation  

Using published data, we found a direct correlation between the incidence of rectal gonorrhea and human immunodeficiency virus (HIV) infection in men who have sex with men who were not using oral preexposure prophylaxis. HIV incidence was predicted using rectal gonorrhea incidence as the determinant in regression analysis. The observed correlation suggest that rectal gonorrhea incidence can potentially serve as a predictor of HIV incidence. If confirmed with additional data, a quantitative correlation for incidence of the 2 infections could be useful in active-controlled HIV prevention trials where low HIV incidence is expected. Widespread improvements in treatment as prevention and gonorrhea control can negatively impact the correlation and its utility.

中文翻译:

与男人发生性关系的男人中的人类免疫缺陷病毒(HIV)感染与直肠淋病发病率之间的相关性:对未来HIV暴露前预防试验的意义。

使用已发表的数据,我们发现与未使用口服前暴露预防措施的男性发生性行为的男性中,直肠淋病的发生率与人类免疫缺陷病毒(HIV)感染之间存在直接的相关性。以直肠淋病的发生率作为回归分析的决定因素来预测HIV的发生率。观察到的相关性表明,直肠淋病的发病率可以潜在地预测艾滋病毒的发病率。如果得到其他数据的证实,则这两种感染的发生率之间的定量相关性在预期艾滋病毒发生率较低的主动控制的艾滋病毒预防试验中可能会有用。预防和淋病控制方面的治疗方面的广泛改进可能会对相关性及其实用性产生负面影响。
更新日期:2019-12-30
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