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Efficient and Divergent Synthesis of Medium‐Sized Lactams through Zinc‐Catalyzed Oxidative Cyclization of Indoly Ynamides†
Chinese Journal of Chemistry ( IF 5.4 ) Pub Date : 2020-01-23 , DOI: 10.1002/cjoc.201900478
Hang‐Hao Li 1 , Si‐Han Ye 1 , Yang‐Bo Chen 1 , Wen‐Feng Luo 2 , Peng‐Cheng Qian 2 , Long‐Wu Ye 1, 3
Affiliation  

An efficient zinc‐catalyzed oxidative cyclization of readily available indoly ynamides has been developed, enabling rapid and practical access to a diverse array of valuable medium‐sized lactams in mostly good to excellent yields with wide substrate scope. In addition, such an asymmetric synthesis has also been explored by employing the chiral substrate.

中文翻译:

通过锌催化的吲哚类酰胺有效高效地合成中型内酰胺†

已开发出一种有效的锌催化氧化环化反应,该反应可轻易获得的二氢吲哚酰胺,可快速实用地获得各种有价值的中型内酰胺,且收率范围从大到优,而且具有广泛的底物范围。另外,还已经通过采用手性底物探索了这种不对称合成。
更新日期:2020-01-23
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