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Follicular T cells: from stability to failure
Allergy ( IF 12.4 ) Pub Date : 2020-02-05 , DOI: 10.1111/all.14167
Rodrigo Jiménez-Saiz 1, 2 , Kelly Bruton 2 , Manel Jordana 2
Affiliation  

The germinal centre (GC) reaction is key for adaptive immunity as it drives the generation of high affinity antibodies that mediate protection against extracellular pathogens. This process entails extensive B cell proliferation, somatic hypermutation of the B cell receptor and affinity maturation. While the GC reaction provides an evolutionary advantage, its dysregulation can trigger the development of diseases such as autoimmunity, hypersensitivity and cancer. Immune regulation, such as the one exerted by regulatory T cells, is a central immunological principle aimed at maintaining homeostasis and preventing pathological responses (1). At the level of the GC, the precise role of follicular regulatory T cells (TFR ) has remained elusive, and even controversial, due to limitations of the current experimental systems.

中文翻译:

滤泡 T 细胞:从稳定到失败

生发中心 (GC) 反应是适应性免疫的关键,因为它驱动产生高亲和力抗体,介导对细胞外病原体的保护。这个过程需要广泛的 B 细胞增殖、B 细胞受体的体细胞超突变和亲和力成熟。虽然 GC 反应提供了进化优势,但其失调会引发自身免疫、超敏反应和癌症等疾病的发展。免疫调节,例如由调节性 T 细胞发挥的调节作用,是一种主要的免疫学原理,旨在维持体内平衡和预防病理反应 (1)。在 GC 水平上,由于当前实验系统的局限性,滤泡调节性 T 细胞 (TFR) 的确切作用仍然难以捉摸,甚至存在争议。
更新日期:2020-02-05
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