To control foot-and-mouth disease (FMD) outbreaks that originated in Jincheon County in South Korea between 2014 and 2015, several commercial vaccines were studied for their efficacy and serological performance in the field. In this study, the efficacy of the O SKR 7/10 vaccine was evaluated by challenge with the FMD virus (FMDV) O/Jincheon/SKR/2014 (O Jincheon), which has the same O/SEA/Mya-98 lineage as the O/SKR/7/10 strain that was isolated in 2010 in South Korea, in FMD-seronegative pigs. Full protection against the O Jincheon virus was demonstrated as early as 14 days postvaccination, which was explained by the strong serological relationship (r1 value: ≥ 0.92) between the O Jincheon and O SKR 2010 viruses. However, in the field trial, no satisfactory serological elevations against FMDV were observed, even in the double-vaccinated groups. Therefore, it can be concluded that the O SKR 7/10 vaccine may need to be improved to overcome the interference effects from the high levels of maternally-derived antibodies generated due to the mandatory nationwide vaccination of sows in South Korea.

中文翻译：

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母源抗体对口蹄疫油乳剂疫苗免疫猪血清学性能的干扰作用。

为了控制2014年至2015年间在韩国镇川县爆发的口蹄疫（FMD）爆发，研究了几种商用疫苗在田间的功效和血清学性能。在这项研究中，通过用口蹄疫病毒（FMDV）O / Jincheon / SKR / 2014（O Jincheon）攻击来评估O SKR 7/10疫苗的功效，该O / Jincheon / SKR / 2014与O / SEA / Mya-98血统相同O / SKR / 7/10株于2010年在韩国分离出，用于FMD血清阴性猪。O Jincheon病毒早在接种疫苗后14天就得到了全面保护，这可以通过O Jincheon病毒与O SKR 2010病毒之间强烈的血清学关系（r1值：≥0.92）来解释。但是，在田间试验中，即使在双重疫苗接种组中也未观察到令人满意的针对FMDV的血清学升高。