Excessive iron accumulation in the heart can lead to iron overload cardiomyopathy (IOC), the leading cause of death in hemochromatosis patients. Current understanding regarding the mechanism by which iron overload causes a deterioration in cardiac performance, mitochondrial dysfunction, and impaired mitochondrial dynamics remains limited. Ferroptosis, a newly identified form of regulated cell death, has recently been revealed influencing the pathophysiological process of IOC. Nevertheless, the direct effect of cardiac iron overload on ferroptotic cell death is incompletely characterized. This review article comprehensively summarizes and discusses the effects of iron overload on cardiac mitochondrial function, cardiac mitochondrial dynamics, ferroptosis of cardiomyocytes, and left ventricular function in in vitro and in vivo reports. This review also provides relevant consistent and controversial information which can facilitate further mechanistic investigation into iron-induced cardiac dysfunction in the clinical setting in the near future.

中文翻译：

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铁超负荷对心肌细胞线粒体功能，线粒体动力学和肥大作用的影响。

心脏中过多的铁蓄积会导致铁过载性心肌病（IOC），这是血色素沉着病患者死亡的主要原因。目前对铁超负荷导致心脏功能恶化，线粒体功能障碍和线粒体动力学受损的机制的理解仍然有限。Ferroptosis是一种新近确定的调控细胞死亡的形式，最近发现它会影响IOC的病理生理过程。然而，心脏铁超负荷对肥大细胞死亡的直接作用尚不完全清楚。这篇综述文章在体外和体内报道中全面总结和讨论了铁超负荷对心脏线粒体功能，心脏线粒体动力学，心肌细胞肥大症和左心室功能的影响。