Abstract Four complexes having the formula [Zn(L)2] [L1 = (C18H20NS2–), N-(4-isopropyl-benzyl)-(benzyl)-dithiocarbamate], [L2 = (C10H12NS2–), N-(benzyl)-(ethyl)-dithiocarbamate], [L3 = (C19H22ONS2–), N-(4-isopropyl-benzyl)-(4-methoxy-benzyl)-dithiocarbamate], and [L4 = (C16H16NS2–), N-(benzyl)-(4-methyl-benzyl)-dithiocarbamate] have been contemplated, synthesized, and characterized by elemental analysis and IR, 1H, 13C NMR and UV–visible absorption spectra. All Zn(II) complexes have similar geometry and coordination number. Complex A2 (with ligand L2) crystallizes in triclinic system with space group P-1 having distorted square pyramidal geometry which was stabilized by weak C–H···π and C–H···S intramolecular interactions. The antibacterial, antibiofilm, and antitumor activities of the complexes have been screened and A2 and A3 showed their prominence. Interestingly, both A2 and A3 showed more killing potential against multi-drug resistant gram-positive isolates with MIC indices of 16 μg mL−1 and 16 μg mL−1, respectively, against both MRSA and MSSA, while the antitumor agent A3 showed its prominence with GI50 and LC50 41.15 and 133.73 µg mL−1, respectively. Graphical Abstract

中文翻译：

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Zn(II) 二硫代氨基甲酸酯复合物作为潜在抗菌剂、抗生物膜剂和抗肿瘤剂的合成和评价

摘要 具有式 [Zn(L)2] [L1 = (C18H20NS2–), N-(4-isopropyl-benzyl)-(benzyl)-dithiocarbamate], [L2 = (C10H12NS2–), N-(benzyl )-(乙基)-二硫代氨基甲酸酯], [L3 = (C19H22ONS2–), N-(4-异丙基-苄基)-(4-甲氧基-苄基)-二硫代氨基甲酸酯], 和 [L4 = (C16H16NS2-), N-(苄基)-(4-甲基-苄基)-二硫代氨基甲酸酯]已被考虑、合成，并通过元素分析和 IR、1H、13C NMR 和紫外-可见吸收光谱表征。所有 Zn(II) 配合物具有相似的几何形状和配位数。配合物 A2（配体 L2）在三斜晶系中结晶，空间群 P-1 具有扭曲的四方锥体几何形状，通过弱 C–H…π 和 C–H…S 分子内相互作用稳定。抗菌、抗生物膜、该复合物的抗肿瘤活性和抗肿瘤活性已被筛选出来，A2和A3显示出它们的突出地位。有趣的是，对于 MRSA 和 MSSA，A2 和 A3 对多重耐药革兰氏阳性分离株显示出更大的杀伤潜力，MIC 指数分别为 16 μg mL-1 和 16 μg mL-1，而抗肿瘤剂 A3 GI50 和 LC50 分别为 41.15 和 133.73 µg mL-1。图形概要