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Prevalence of sarcopenia as a comorbid disease: A systematic review and meta-analysis.
Experimental Gerontology ( IF 3.9 ) Pub Date : 2019-12-27 , DOI: 10.1016/j.exger.2019.110801
Jacob Pacifico 1 , Milou A J Geerlings 2 , Esmee M Reijnierse 1 , Christina Phassouliotis 1 , Wen Kwang Lim 1 , Andrea B Maier 3
Affiliation  

BACKGROUND Sarcopenia shares risk factors with various other age-related diseases. This meta-analysis aimed to determine the prevalence of sarcopenia as a comorbid disease. METHODS Medline, EMBASE and Cochrane databases were searched for articles from inception to 8th June 2018, reporting the prevalence of sarcopenia in individuals with a diagnosis of cardiovascular disease (CVD), dementia, diabetes mellitus or respiratory disease and, if applicable their controls. No exclusion criteria were applied with regards to definition of sarcopenia, individuals' age, study design and setting. Meta-analyses were stratified by disease, definition of sarcopenia and continent. RESULTS The 63 included articles described 17,206 diseased individuals (mean age: 65.3 ± 1.6 years, 49.9% females) and 22,375 non-diseased controls (mean age: 54.6 ± 16.2 years, 53.8% females). The prevalence of sarcopenia in individuals with CVD was 31.4% (95% CI: 22.4-42.1%), no controls were available. The prevalence of sarcopenia was 26.4% (95% CI: 13.6-44.8%) in individuals with dementia compared to 8.3% (95% CI: 2.8-21.9%) in their controls; 31.1% (95% CI: 19.8-45.2%) in individuals with diabetes mellitus compared to 16.2% (95% CI: 9.5-26.2%) in controls; and 26.8% (95% CI: 17.8-38.1%) in individuals with respiratory diseases compared to 13.3% (95% CI: 8.3-20.7%) in controls. CONCLUSIONS Sarcopenia is highly prevalent in individuals with CVD, dementia, diabetes mellitus and respiratory disease.

中文翻译:

少肌症作为合并症的患病率:系统评价和荟萃分析。

背景技术少肌症与多种其他与年龄有关的疾病共享危险因素。这项荟萃分析旨在确定少肌症作为合并症的患病率。方法从Medline,EMBASE和Cochrane数据库中检索从开始到2018年6月8日的文章,报告患有诊断为心血管疾病(CVD),痴呆,糖尿病或呼吸系统疾病的患者(如果适用)及其对照的少肌症的患病率。对于肌肉减少症的定义,个体年龄,研究设计和设置,未应用任何排除标准。荟萃分析按疾病,肌肉减少症的定义和大陆分类。结果包括63篇文章描述了17206名患病个体(平均年龄:65.3±1.6岁,女性49.9%)和22375名未患病对照(平均年龄:54.6±16.2岁,53岁)。8%的女性)。CVD患者的肌肉减少症的患病率为31.4%(95%CI:22.4-42.1%),尚无对照。痴呆症患者的肌肉减少症患病率为26.4%(95%CI:13.6-44.8%),而对照组为8.3%(95%CI:2.8-21.9%)。糖尿病患者中31.1%(95%CI:19.8-45.2%),而对照组为16.2%(95%CI:9.5-26.2%);患呼吸系统疾病的个体为26.8%(95%CI:17.8-38.1%),而对照组为13.3%(95%CI:8.3-20.7%)。结论肌肉减少症在患有CVD,痴呆,糖尿病和呼吸系统疾病的个体中非常普遍。对照组中占3%(95%CI:2.8-21.9%);糖尿病患者中31.1%(95%CI:19.8-45.2%),而对照组为16.2%(95%CI:9.5-26.2%);患呼吸系统疾病的个体为26.8%(95%CI:17.8-38.1%),而对照组为13.3%(95%CI:8.3-20.7%)。结论肌肉减少症在患有CVD,痴呆,糖尿病和呼吸系统疾病的个体中非常普遍。对照组中有3%(95%CI:2.8-21.9%);糖尿病患者中31.1%(95%CI:19.8-45.2%),而对照组为16.2%(95%CI:9.5-26.2%);患呼吸系统疾病的个体为26.8%(95%CI:17.8-38.1%),而对照组为13.3%(95%CI:8.3-20.7%)。结论肌肉减少症在患有CVD,痴呆,糖尿病和呼吸系统疾病的个体中非常普遍。
更新日期:2019-12-29
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