A new DNA nanoprobe based on a Y-shape and pyrene-modified DNA self-assembly is developed to sensitively and specifically detect microRNA through a pyrene excimer-monomer switch. Exhibiting the capability of self-delivery and resistance to nuclease degradation, the nanoprobe has been successfully applied for microRNA imaging in live cells.

中文翻译：

---

一种自我传递的DNA纳米探针，通过聚集诱导的红移发射，可在活细胞中进行可靠的microRNA成像。

开发了一种基于Y形和pyr修饰的DNA自组装的新DNA纳米探针，可通过a准分子-单体开关灵敏且特异地检测microRNA。纳米探针具有自我传递的能力和对核酸酶降解的抗性，已成功应用于活细胞中的microRNA成像。