To explore the early predictors of post-operative recurrence and metastasis of rectal cancer, analyse the associated risk, and construct a model. Retrospective collection. Four hundred patients with rectal cancer underwent surgical resection and pathological diagnosis from September 2013 to September 2014. During the post-operative period, the patients were tested by imaging examination, serum tumour markers, and routine blood follow-up for at least 3 years. Preoperative CT examination of tumour size, lymphocyte-to-neutrophil ratio, and CEA were significant biomarkers for predicting recurrence and/or metastasis of post-operative rectal cancer. The stratified threshold of the lesion size cut-off point in CT images of patients with rectal cancer was 18.75 cm3, the cut-off point value of the lymphocyte-to-neutrophil ratio was 0.33, and the CEA cut-off point value was 16.97 ng/ml. We used the cut-off point to perform stratified survival analysis to obtain two K-M curves and conduct a log-rank test. The Cox multivariate risk regression results were as follows: preoperative CT images of lesion size, lymphocyte-to-neutrophil ratio, and CEA. The AUC of the normogram model for the prediction of post-operative recurrence and metastasis of rectal cancer is 0.939. Preoperative CT examination of tumour size can predict post-operative recurrence and metastasis of rectal cancer and can be used to analyse its risk. The lymphocyte-to-neutrophil ratio and CEA can also predict post-operative tumour recurrence and metastasis risk.

中文翻译：

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多层螺旋CT图像结合CEA和淋巴细胞/嗜中性粒细胞比率预​​测直肠癌的复发和术后转移。

为了探讨直肠癌术后复发和转移的早期预测因素，分析相关风险，并建立模型。回顾性收藏。2013年9月至2014年9月，对400例直肠癌患者进行了手术切除和病理诊断。在术后期间，对患者进行影像学检查，血清肿瘤标志物和常规血液随访至少3年。术前CT检查肿瘤大小，淋巴细胞与嗜中性粒细胞比率以及CEA是预测术后直肠癌复发和/或转移的重要生物标志物。直肠癌患者CT影像的病变大小分界点的分层阈值为18.75 cm3，淋巴细胞与中性粒细胞之比的分界点值为0.33，CEA临界点值为16.97 ng / ml。我们使用分界点进行分层生存分析，以获得两条KM曲线并进行对数秩检验。Cox多元风险回归结果如下：术前CT图像显示的是病变大小，淋巴细胞与中性粒细胞的比率以及CEA。预测直肠癌术后复发和转移的范数图模型的AUC为0.939。术前CT检查肿瘤大小可预测直肠癌的术后复发和转移，并可用于分析其风险。淋巴细胞与中性粒细胞的比率和CEA也可以预测术后肿瘤复发和转移的风险。Cox多元风险回归结果如下：术前CT图像显示的是病变大小，淋巴细胞与中性粒细胞的比率以及CEA。预测直肠癌术后复发和转移的范数图模型的AUC为0.939。术前CT检查肿瘤大小可预测直肠癌的术后复发和转移，并可用于分析其风险。淋巴细胞与中性粒细胞的比率和CEA也可以预测术后肿瘤复发和转移的风险。Cox多元风险回归结果如下：术前CT图像显示的是病变大小，淋巴细胞与中性粒细胞的比率以及CEA。预测直肠癌术后复发和转移的范数图模型的AUC为0.939。术前CT检查肿瘤大小可预测直肠癌的术后复发和转移，并可用于分析其风险。淋巴细胞与中性粒细胞的比率和CEA也可以预测术后肿瘤复发和转移的风险。术前CT检查肿瘤大小可预测直肠癌的术后复发和转移，并可用于分析其风险。淋巴细胞与中性粒细胞的比率和CEA也可以预测术后肿瘤复发和转移的风险。术前CT检查肿瘤大小可预测直肠癌的术后复发和转移，并可用于分析其风险。淋巴细胞与中性粒细胞的比率和CEA也可以预测术后肿瘤复发和转移的风险。