A novel colorimetric fluorescent probe Mito-PF was constructed base on ICT strategy, which showed a 30-fold enhancement of fluorescence intensity toward fluoride ion (F⁻) with excellent sensitivity and high selectivity. The response of the probe to fluoride ion is ascribed to the cleavage reaction of SiO bond, then releases fluorescent group with intense green fluorescence signals realizing turn-on fluorescence responses. Probe Mito-PF shows good cell membrane permeability and can be successfully located in mitochondria to monitor fluoride ion in living cells, which is of great significance for biological research and clinical diagnostic.

中文翻译：

---

基于ICT的荧光探针可检测细胞线粒体中的氟离子

一种新颖的比色荧光探针三刀-PF建在ICT策略，这表现出对氟离子（F荧光强度的30倍的增强基^- ）具有优良的灵敏度和高的选择性。探针对氟离子的响应归因于Si O键的裂解反应，然后释放出带有强烈绿色荧光信号的荧光基团，从而实现了开启的荧光响应。Mito-PF探针显示出良好的细胞膜通透性，可以成功地位于线粒体中以监测活细胞中的氟离子，这对生物学研究和临床诊断具有重要意义。