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Palladium-catalyzed tandem oxidative annulation of α-amino ketones leading to 2-aroylindoles
Tetrahedron ( IF 2.1 ) Pub Date : 2019-12-28 , DOI: 10.1016/j.tet.2019.130917 Tao-Shan Jiang , Long Dai , Yuhui Zhou , Xiuli Zhang
中文翻译:
钯催化的α-氨基酮的串联氧化氧化反应生成2-芳基吲哚
更新日期:2019-12-29
Tetrahedron ( IF 2.1 ) Pub Date : 2019-12-28 , DOI: 10.1016/j.tet.2019.130917 Tao-Shan Jiang , Long Dai , Yuhui Zhou , Xiuli Zhang
A simple synthesis of 2-aroylindoles via palladium-catalyzed tandem oxidative annulation directly from α-amino ketones has been developed. In this transformation, two-step reaction including oxidation of α-amino aetones to generate imine intermediates and subsequent palladium-catalyzed aerobic annulation to give 2-aroylindoles was compatible in one pot.
中文翻译:
钯催化的α-氨基酮的串联氧化氧化反应生成2-芳基吲哚
已经开发了直接由α-氨基酮通过钯催化的串联氧化环化反应合成2-芳基吲哚的简单方法。在该转化中,两步反应在一个罐中兼容,该反应包括将α-氨基酮氧化以生成亚胺中间体,然后进行钯催化的好氧环化以生成2-芳酰基吲哚。