A base promoted diastereoselective formal [3+3] cycloaddition reaction of 2-arylideneindan-1,3-diones with β-naphthols towards the synthesis of functionalized pentacyclic indeno[1], [2], [2](a), [2](b)chromen-(4bH)-ones has been developed. This methodology is appreciated in terms of diastereoselectivity and mild conditions. In addition, the immunosuppressive assay indicates that one of the products has selective inhibition on T-cell proliferation (IC₅₀ value of 8.73 μM).

中文翻译：

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β-萘酚与2-芳基茚满-1,3-二酮的非对映选择性[3 + 3]环加成反应：免疫抑制性五环环烷的高效组装

碱促进2-芳基茚满-1,3-二酮与β-萘酚的非对映选择性形式[3 + 3]环加成反应，以合成功能化的五环茚并[1]，[2]，[2]（a），[2]已经开发了[ ]（b）chromen-（4b H）-ones。就非对映选择性和温和条件而言，该方法受到赞赏。此外，免疫抑制分析表明其中一种产物对T细胞增殖具有选择性抑制作用（IC ₅₀值为8.73μM）。