BACKGROUND Admission hyperglycemia (HG) has been associated with worse outcomes among acute stroke patients. A better understanding and awareness of the potentially adverse influence of hyperglycemia on the clinical outcome of acute stroke patients would help to provide guidance for acute stroke management and prevention of its adverse outcomes. We aimed to assess the frequency of admission hyperglycemia and its impact on short term (30-days) morbidity and mortality outcomes of stroke in adult Ethiopian patients in an urban setting. METHODS A prospective, cross-sectional study was conducted among acute stroke patients admitted to Tikur Anbessa Specialized Hospital (TASH), within 72 h of symptom onset, from July to December 2016. Socio-demographic data, neuroimaging findings and capillary blood glucose values were obtained on admission. Hyperglycemia was defined as > 140 mg/dl. National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) were used to assess the baseline stroke severity and the 30-days post-stroke outcome, respectively. RESULTS A total of 103 first-ever acute stroke patients were included (mean age = 55.5 + 15.3 years, 64.1% male and 65% under the age of 65 years) and 51 (49.5%) were hyperglycemic at time of admission. The median admission NIHSS score was worse in the hyperglycemic patients 14 (IQR 10-19) compared to normoglycemic patients 11 (IQR 8-15). Among stroke survivors, patients with hyperglycemia were 3.83 times (95% CI, 1.99-6.19) more likely to be functionally impaired (mRS = 3-5) at 30-days compared to normoglycemic patients (P = 0.041).Older age (≥ 65 years) (P = 0.017) and stroke severity (NIHSS > 14) (P = 0.006) at admission were both significantly associated with poor functional recovery at 30-day. Among patients who died at 30-day, two-third (66.7%) were hyperglycemic but they failed to show any significant association. CONCLUSIONS Hyperglycemia is prevalent among Ethiopian stroke patients at the time of presentation and it is associated with significantly poor functional recovery at 30th-day of follow up. This finding provides a rationale for achieving normal blood glucose in the course of acute stroke management which could have a favorable impact on the neurological outcome and quality of life for patients.

中文翻译：

---

入院高血糖的频率和对入入埃塞俄比亚亚的斯亚贝巴的提库尔·安贝萨专科医院的急性卒中患者短期预后的影响：一项横断面研究。

背景技术急性卒中患者的入院高血糖症（HG）与较差的预后相关。更好地了解和认识高血糖对急性中风患者的临床结局的潜在不利影响将有助于为急性中风的治疗和预防其不良结局提供指导。我们旨在评估在城市环境中成年埃塞俄比亚患者的入院高血糖频率及其对短期（30天）卒中发病率和死亡率的影响。方法从2016年7月至2016年12月，在症状发作的72小时内，对入院Tikur Anbessa专科医院（TASH）的急性中风患者进行了一项前瞻性横断面研究。入场时获得。高血糖定义为> 140 mg / dl。美国国立卫生研究院卒中量表（NIHSS）和改良的兰金量表（mRS）分别用于评估基线卒中严重程度和卒中后30天的结果。结果共纳入103例首次急性卒中患者（平均年龄55.5 + 15.3岁，男性64.1％，65岁以下男性65％），入院时有51例血糖升高（49.5％）。与正常血糖患者11（IQR 8-15）相比，高血糖患者14（IQR 10-19）的入院NIHSS评分更差。在中风幸存者中，高血糖患者在30天时比正常血糖患者（P = 0.041）高3.83倍（95％CI，1.99-6.19）出现功能障碍的可能性更高（mRS = 3-5）。 65岁）（P = 0.017）和中风严重度（NIHSS> 14）（P = 0。006）入院时均与30天的不良功能恢复显着相关。在30天死亡的患者中，三分之二（66.7％）为高血糖，但未显示任何显着相关性。结论高血糖症在埃塞俄比亚卒中患者中很常见，并且在随访30天时功能恢复明显不佳。这一发现为急性卒中治疗过程中达到正常血糖水平提供了理论依据，这可能会对患者的神经系统结局和生活质量产生有利影响。结论高血糖症在埃塞俄比亚卒中患者中很常见，并且在随访30天时功能恢复明显不佳。这一发现为急性卒中治疗过程中达到正常血糖水平提供了理论依据，这可能会对患者的神经系统结局和生活质量产生有利影响。结论高血糖症在埃塞俄比亚卒中患者中很常见，并且在随访30天时功能恢复明显不佳。这一发现为急性卒中治疗过程中达到正常血糖水平提供了理论依据，这可能会对患者的神经系统结局和生活质量产生有利影响。