The chirality of nanoparticles directly influences their transport and biological effects under physiological conditions, but the details of this phenomenon have rarely been explored. Herein, chiral GSH-anchored selenium nanoparticles (G@SeNPs) are fabricated to investigate the effect of their chirality on their transport and antioxidant activity. G@SeNPs modified with different enantiomers show opposite handedness with a tunable circular dichroism signal. Noninvasive positron emission tomography imaging clearly reveals that 64 Cu-labeled l-G@SeNPs experience distinctly different transport among the major organs from that of their d-and dl-counterparts, demonstrating that the chirality of the G@SeNPs influences the biodistribution and kinetics. Taking advantage of the strong homologous cell adhesion and uptake, l-G@SeNPs have been shown here to effectively prevent oxidation damage caused by palmitic acid in insulinoma cells.

中文翻译：

---

手性硒纳米颗粒的手性驱动的运输和氧化预防。

纳米粒子的手性直接影响其在生理条件下的运输和生物效应，但这种现象的细节很少被探索。在此，制备了手性谷胱甘肽锚定的硒纳米颗粒（G@SeNPs），以研究其手性对其转运和抗氧化活性的影响。用不同对映体修饰的 G@SeNPs 显示出相反的旋向性和可调的圆二色性信号。无创正电子发射断层扫描成像清楚地揭示了 64 个 Cu 标记的 lG@SeNPs 在主要器官之间经历了与其 d-和 dl-对应物明显不同的运输，表明 G@SeNPs 的手性影响生物分布和动力学。利用强大的同源细胞粘附和摄取作用，IG@SeNPs 已被证明可以有效防止胰岛素瘤细胞中棕榈酸引起的氧化损伤。