The postsynaptic density (PSD) is a complex subcellular domain important for postsynaptic signaling, function, and plasticity. The PSD is present at excitatory synapses and specialized to allow for precise neuron-to-neuron transmission of information. The PSD is localized immediately underneath the postsynaptic membrane forming a major protein network that regulates postsynaptic signaling and synaptic plasticity. Glutamatergic synaptic dysfunction affecting PSD morphology and signaling events have been described in many neurodegenerative disorders, either sporadic or familial forms. Thus, in this review we describe the main protein players forming the PSD and their activity, as well as relevant modifications in key components of the postsynaptic architecture occurring in Huntington's, Parkinson's and Alzheimer's diseases.

中文翻译：

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神经退行性疾病中修饰的谷氨酸能后突触。

突触后密度 (PSD) 是一个复杂的亚细胞结构域，对突触后信号传导、功能和可塑性很重要。PSD存在于兴奋性突触中，专门用于允许精确的神经元到神经元的信息传输。PSD 位于突触后膜下方，形成调节突触后信号传导和突触可塑性的主要蛋白质网络。影响 PSD 形态和信号事件的谷氨酸能突触功能障碍已在许多神经退行性疾病中得到描述，无论是散发性还是家族性形式。因此，在这篇综述中，我们描述了形成 PSD 的主要蛋白质参与者及其活性，以及​​亨廷顿病、帕金森病和阿尔茨海默病中发生的突触后结构关键成分的相关修饰。