A series of novel 1,2,4‐triazol derivatives containing an amide moiety were synthesized and their antifungal activities were evaluated. The results indicated that some of the target compounds possessed good antifungal activities. Among them, compounds 6a, 6g, 6k, and 6m showed excellent antifungal activities against Botrytis cinerea, with an inhibition rate of 91.8%, 90.1%, 93.6%, and 91.2% at a concentration of 50 μg/mL, which were superior to that of Pyrimethanil (82.8%). Meanwhile, compound 6b showed better antifungal activity against Phompsis sp, with an inhibition rate of 92.4%, in comparison with that of Pyrimethanil (85.1%).

中文翻译：

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含有酰胺部分的新型1,2,4-三唑衍生物的合成及抗真菌活性

合成了一系列含有酰胺部分的新型1,2,4-三唑衍生物，并评估了它们的抗真菌活性。结果表明，某些目标化合物具有良好的抗真菌活性。其中，化合物6a，6g，6k和6m对灰葡萄孢具有优异的抗真菌活性，在浓度为50μg/ mL时抑制率分别为91.8％，90.1％，93.6％和91.2％，优于嘧菌胺的比例为82.8％。同时，化合物6b显示出对Phompsis sp的更好的抗真菌活性，与嘧菌胺（85.1％）相比具有92.4％的抑制率。