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Core-Shell Encapsulation of Lipophilic Substance in Jelly Fig (Ficus awkeotsang Makino) Polysaccharides Using an Inexpensive Acrylic-Based Millifluidic Device.
Applied Biochemistry and Biotechnology ( IF 3 ) Pub Date : 2019-12-26 , DOI: 10.1007/s12010-019-03209-5
Thangavel Ponrasu,Ren-Fang Yang,Tzung-Han Chou,Jia-Jiuan Wu,Yu-Shen Cheng

The polysaccharides extracted from the achenes of jelly fig, Ficus awkeotsang Makino, were mainly composed of low methyl pectin and used as a novel shell material for encapsulating lipophilic bioactives in the core of microcapsule. The polysaccharide microcapsules with oil core were prepared using a novel acrylic-based millifluidic device developed in this study. To investigate the physiochemical properties of and find the suitable formula of polysaccharide shells, the films casted with jelly fig polysaccharide were thoroughly characterized. For the preparation of microcapsules, the millifluidic device was optimized by controlling the flow rate to obtain uniform spherical shape with a core diameter of 1.4-1.9 mm and the outer diameter of 2.1-2.8 mm. The encapsulation efficiency was around 90%, and the microcapsules displayed a clear boundary between the polysaccharide shell and oil core. Encapsulation of curcumin in the microcapsules was prepared to test the applicability of the device and processes developed in this study, and the results showed that the microencapsulation could enhance the stability of curcumin against external environment. Overall, the results suggested that the jelly fig polysaccharides and the developed millifluidic device can be useful for the preparation of core-shell microcapsules for encapsulation of lipophilic bioactives.

中文翻译:

使用廉价的基于丙烯酸的微流控设备在果冻无花果(无花果Makino)多糖中亲脂性物质的核-壳封装。

从果冻无花果瘦果中提取的多糖,主要由低甲基果胶组成,并被用作一种新型的外壳材料,将亲脂性生物活性物质封装在微胶囊的核心。使用本研究开发的新型丙烯酸基微流控装置制备了具有油核的多糖微囊。为了研究多糖壳的理化特性并找到合适的配方,对果冻无花果多糖流延膜进行了彻底的表征。为了制备微胶囊,通过控制流速来优化微流体装置以获得具有1.4-1.9mm的芯直径和2.1-2.8mm的外径的均匀球形。封装效率约为90%,微胶囊在多糖壳和油核之间显示出清晰的边界。准备姜黄素在微囊中的包封以测试本研究开发的装置和工艺的适用性,结果表明微囊可以增强姜黄素对外部环境的稳定性。总体而言,结果表明果冻无花果多糖和发达的微流控装置可用于制备用于包封亲脂性生物活性物质的核壳微胶囊。结果表明,微囊化可以增强姜黄素对外界环境的稳定性。总体而言,结果表明果冻无花果多糖和发达的微流控装置可用于制备用于包封亲脂性生物活性物质的核壳微胶囊。结果表明,微囊化可以增强姜黄素对外界环境的稳定性。总体而言,结果表明果冻无花果多糖和发达的微流控装置可用于制备用于包封亲脂性生物活性物质的核壳微胶囊。
更新日期:2019-12-27
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