INTRODUCTION Pregnancy management in women with Wilson disease (WD) remains an important clinical problem. This research was conducted to investigate how to avoid worsening of WD symptoms during pregnancy and increase pregnancy success in women with WD by identifying the best pregnancy management approaches in these patients. PATIENTS AND METHODS The clinical data of 117 pregnancies among 75 women with WD were retrospectively analyzed. Related information of the fetus was also recorded and analyzed. At the same time, regression analysis was performed for data of 22 pregnant women without WD, as normal controls. RESULTS Of a total of 117 pregnancies among the 75 women with WD and 31 pregnancies among the 22 control womenincluded in this study, there were 108 successful pregnancies and 9 spontaneous abortions. Among the 108 successful pregnancies, 97 women a history of copper chelation therapy before pregnancy; all 97 women stopped anti-copper therapy during pregnancy. The nine women with spontaneous abortion had no pre-pregnancy history of copper displacement therapy. The incidence of lower limb edema was higher in the WD group than in normal controls (P = 0.036). Compared with the control group, there was a higher proportion in the WD group of male infants (P = 0.022) and lower average infant birth weight (t = 3.514, P = 0.001). CONCLUSION It is relatively safe for women with WD patients to become pregnant. The best management method for pregnancy in women with WD may be intensive pre-pregnancy copper chelation therapy and no anti-copper treatment during pregnancy.

中文翻译：

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威尔逊病在妊娠管理中的研究。

引言威尔逊病（WD）妇女的妊娠管理仍然是一个重要的临床问题。通过确定这些患者的最佳妊娠管理方法，进行了这项研究以探讨如何避免在妊娠期间WD症状加重和增加WD妇女的妊娠成功率。病人与方法回顾性分析了75例WD妇女中117例妊娠的临床资料。胎儿的相关信息也被记录和分析。同时，对作为正常对照的22名无WD孕妇的数据进行了回归分析。结果本研究纳入的75例WD妇女中，共有117例妊娠，而22例对照妇女中，共有31例，其中成功妊娠108例，自然流产9例。在108次成功怀孕中，97名女性在怀孕前有铜螯合疗法的病史；所有97名妇女在怀孕期间都停止了抗铜治疗。九名自然流产的妇女在怀孕前无铜置换治疗史。WD组下肢水肿的发生率高于正常对照组（P = 0.036）。与对照组相比，WD组的男婴比例更高（P = 0.022），平均婴儿出生体重更低（t = 3.514，P = 0.001）。结论WD患者的妇女怀孕是相对安全的。WD妇女妊娠的最佳管理方法可能是强化孕前铜螯合疗法，并且在怀孕期间不进行抗铜治疗。九名自然流产的妇女在怀孕前无铜置换治疗史。WD组下肢水肿的发生率高于正常对照组（P = 0.036）。与对照组相比，WD组的男婴比例更高（P = 0.022），平均婴儿出生体重更低（t = 3.514，P = 0.001）。结论WD患者的妇女怀孕是相对安全的。WD妇女妊娠的最佳管理方法可能是强化孕前铜螯合疗法，并且在怀孕期间不进行抗铜治疗。九名自然流产的妇女在怀孕前无铜置换治疗史。WD组下肢水肿的发生率高于正常对照组（P = 0.036）。与对照组相比，WD组的男婴比例更高（P = 0.022），平均婴儿出生体重更低（t = 3.514，P = 0.001）。结论WD患者的妇女怀孕是相对安全的。WD妇女妊娠的最佳管理方法可能是强化孕前铜螯合疗法，并且在怀孕期间不进行抗铜治疗。在WD组中，男性婴儿的比例较高（P = 0.022），而婴儿平均出生体重较低（t = 3.514，P = 0.001）。结论WD患者的妇女怀孕是相对安全的。WD妇女妊娠的最佳管理方法可能是强化孕前铜螯合疗法，并且在怀孕期间不进行抗铜治疗。在WD组中，男性婴儿的比例较高（P = 0.022），而婴儿平均出生体重较低（t = 3.514，P = 0.001）。结论WD患者的妇女怀孕是相对安全的。WD妇女妊娠的最佳管理方法可能是强化孕前铜螯合疗法，并且在怀孕期间不进行抗铜治疗。